州大学大学院学研究院
創薬育薬産学官連携分野
 Department of Drug Discovery and Evolution
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2013-2015業績はこちら
 【業 績】
 投稿論文
  2018年

Masumi KATANE, Makoto ARIYOSHI, Shuhei TATEISHI, Sachi KOIWAI, Kaoruko TAKAKU, Kenichiro NAGAI, Kazuki NAKAYAMA, Yasuaki SAITOH, Tetsuya MIYAMOTO, Masae SEKINE, Masashi MITA, Kenji HAMASE, Satoaki MATOBA, Hiroshi HOMMA, Structural and enzymatic properties of mammalian D-glutamate cyclase,
Archives of Biochemistry and Biophysics, in press,

 

Yusuke NAKADE, Yasunori IWATA, Kengo FURUICHI, Masashi MITA, Kenji HAMASE, Ryuichi KONNO, Taito MIYAKE, Norihiko SAKAI, Shinji KITAJIMA, Tadashi TOYAMA, Yasuyuki SHINOZAKI, Akihiro SAGARA, Taro MIYAGAWA, Akinori HARA, Miho SHIMIZU, Yasutaka KAMIKAWA, Kouichi SATO, Megumi OSHIMA, Shiori YONEDA-NAKAGAWA, Yuta Yamamura, Shuichi KANEKO, Tetsuya MIYAMOTO, Masumi KATANE, Hiroshi HOMMA, Hidetoshi MORITA, Wataru SUDA, Masahira HATTORI, Takashi WADA, Gut microbiota-derived D-serine protects from acute kidney injury,
JCI Insight
,
in press,


Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Kenji HAMASE, Development of an online two-dimensional high-performance liquid chromatographic system in combination with tandem mass spectrometric detection for enantiomeric analysis of free amino acids in human physiological fluid,
Journal of Chromatography A
,1570, 91-98 (2018), DOI:10.1016/j.chroma.2018.07.076


Aogu FURUSHO, Reiko KOGA, Takeyuki AKITA, Yurika MIYOSHI, Masashi MITA, Kenji HAMASE, Development of a highly-sensitive two-dimensional HPLC system with narrowbore reversed-phase and microbore enantioselective columns and application to the chiral amino acid analysis of the mammalian brain,
Chromatography
, 39, 83-90 (2018), DOI:10.15583/jpchrom.2018.007


Nutchaya SEREEKITTIKUL, Reiko KOGA, Takeyuki AKITA, Aogu FURUSHO, Roland REISCHL, Masashi MITA, Akira FUJII, Kazunori HASHIGUCHI, Masanobu NAGANO, Wolfgang LINDNER, Kenji HAMASE, Multi-dimensional HPLC analysis of serine containing chiral dipeptides in Japanese traditional amber rice vinegar,
Chromatography, 39, 59-66 (2018), DOI: 10.15583/jpchrom.2018.002 

  2017年

Chin-Ling HSIEH, Reiko KOGA, Aogu FURUSHO, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Jen-Ai LEE, Kenji HAMASE, Enantioselective and simultaneous determination of lactate and 3-hydroxybutyrate in human plasma and urine using a narrowbore online two-dimensional HPLC system,
Journal of Separation Science, 41, 1298-1306, DOI:10.1002/jssc.201701283


 
Chiharu ISHII, Tetsuya MIYAMOTO, Shoto ISHIGO, Yurika MIYOSHI, Masashi MITA, Hiroshi HOMMA, Tadashi UEDA, Kenji HAMASE, Two-dimensional HPLC-MS/MS determination of multiple D-amino acid residues in the proteins stored under various pH conditions,
Chromatography
, 38, 65-72 (2017), DOI:10.15583/jpchrom.2017.009


Akiko MORIKAWA, Hideoki FUKUOKA, Keiko UEZONO, Masashi MITA, Satoru KOYANAGI, Shigehiro OHDO, Kiyoshi ZAITSU, Kenji HAMASE, Sleep-awake profile related circadian D-alanine rhythm in human serum and urine, Chromatography, 38,53-58(2017), DOI:10.15583/jpchrom.2017.003

 

Makoto ARIYOSHI, Masumi KATANE, Kenji HAMASE, Yurika MIYOSHI, Maiko NAKANE, Atsushi HOSHINO, Yoshifumi OKAWA, Yuichiro MITA, Satoshi KAIMOTO, Motoki UCHIHASHI, Kuniyoshi FUKAI, Kazunori ONO, Syuhei TATEISHI, Daichi HATO, Ryoetsu YAMANAKA, Sakiko HONDA, Yohei FUSHIMURA, Eri IWAI-KANAI, Naotada ISHIHARA, Masashi MITA, Hiroshi HOMMA, Satoaki MATOBA, D-Glutamate is metabolized in the heart mitochondria,
Scientific Reports, 7, 43911 (2017), DOI:10.1038/srep43911


  2016年

Muneki ISOKAWA, Kentaro KOBAYASHI, Yurika MIYOSHI, Masashi MITA, Takashi FUNATSU, Kenji HAMASE, Makoto TSUNODA, Quantification of biological thiols in the plasma of a homocystinuria model with cystathionine β-synthase deficiency utilizing hydrophilic interaction liquid chromatography and fluorescence detection,
Chromatography,
37, 147-151 (2016), DOI:10.15583/jpchrom.2016.015

 
Reiko KOGA, Yurika MIYOSHI, Yu SATO, Masashi MITA, Ryuichi KONNO, Wolfgang LINDNER, Kenji HAMASE, Enantioselective determination of citrulline and ornithine in the urine of D-amino acid oxidase deficient mice using a two-dimensional high-performance liquid chromatographic system,
Journal of Chromatography A
, 1467, 312-317 (2016), DOI:10.1016/j.chroma.2016.07.053

Jumpei SASABE, Yurika MIYOSHI, Seth Rakoff-NAHOUM, Ting ZHANG, Masashi MITA, Brigid M. DAVIS, Kenji HAMASE, Matthew K. WALDOR, Interplay between microbial D-amino acids and host D-amino acid oxidase modifies murine mucosal defence and gut microbiota,
Nature Microbiology, in press, DOI:
10.1038/nmicrobiol.2016.125

 
Tomonori KIMURA, Kenji HAMASE, Yurika MIYOSHI, Ryohei YAMAMOTO, Keiko YASUDA, Masashi MITA, Hiromi RAKUGI, Terumasa HAYASHI, Yoshitaka ISAKA, Chiral amino acid metabolomics for novel biomarker screening in the prognosis of chronic kidney disease,

Scientific Reports, 6,26137 (2016), DOI:10.1038/srep26137

 
 

Minoru TANIGAWA, Chihiro SUZUKI, Kimio NIWANO, Rensuke KANEKATSU, Hiroyuki TANAKA, Kihachiro HORIIKE, Kenji HAMASE, Yoko NAGATA, Participation of D-serine in the development and reproduction of the silkworm Bombyx mori,
Journal of Insect Physiology
, 87, 20-29 (2016). DOI: 10.1016/j.jinsphys.2016.01.006.


Reiko KOGA, Yurika MIYOSHI, Yu SATO, Masashi MITA, Ryuichi KONNO, Wolfgang LINDNER, Kenji HAMASE, Enantioselective determination of phenylalanine, tyrosine and 3,4-dihydroxyphenylalanine in the urine of D-amino acid oxidase deficient mice using two-dimensional high-performance liquid chromatography,
Chromatography
, 37, 1, 15-22 (2016) , DOI:10.15583/jpchrom.2015.040
 


 総説 
  2017年

Haruna SUGAHARA, Cornelia MEINERT, Laurent NAHON, Nykola C. JONES, Soeren V. HOFFMANN, Kenji HAMASE, Yoshinori TAKANO, Uwe J. MEIERHENENRICH, D-Amino acids in molecular evolution in space - absolute asymmetric photolysis and synthesis of amino acids by circularly polarized light,
Biochimica et Biophysica Acta,in press.

 

Reiko KOGA, Yurika MIYOSHI, Hiroaki SAKAUE, Kenji HAMASE, Ryuichi KONNO, Mouse D-amino-acid oxidase: Distribution and physiological substrates,
Frontiers in Molecular Biosciences
, 4, article 82 (2017). DOI:10.3389/fmolb.2017.00082


 著書 
  2017年

浜瀬健司, 光学分割 (3.2.5), 能田 均,萩中 淳,山口政俊編, パートナー分析化学U 改定第3,南江堂,東京, 2017, pp. 178-184.


Reiko KOGA, Yurika MIYOSHI, Kenichiro TODOROKI, Kenji HAMASE, Amino acid and bioamine separations (Chapter 4), in Salvatore FANALI, Paul R. HADDAD, Colin F. POOLE, Marja - Liisa RIEKKOLA (Eds.), Liquid Chromatography (vol. 2, Applications), Elsevier, Amsterdam, 2017.1, pp. 87-106.


 国際学会発表  
  2018年

Takeyuki AKITA, Asumi YOSHIDA, Masashi MITA, Akio OJIDA, Kenji HAMASE, A novel fluorescence derivatizing reagent for chiral amino acid metabolome analysis including tryptophan with high emission intensity, 15th Conference of the International Society of Tryptophan Research (Hikone, 2018 September 20), P98.

  

Kenji HAMASE, Chiral amino acid analysis using multi-dimensional HPLC: A new frontier of the amino acid and protein research,
15th Conference of the International Society of Tryptophan Research (Hikone, 2018 September 20), P67.

【招待講演】

 

Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Kenji HAMASE, Development and validation of an on-line two-dimensional HPLC-MS/MS system for the determination of intrinsic chiral amino acids in human physiological fluids,
The 11th International Symposium on Drug Analysis & The 29th International Symposium on Pharmaceutical and Biomedical Analysis (Leuven, Belgium, 2018 September 9-12)

First Poster Prize

 

Kenji HAMASE, Chiharu ISHII, Aogu FURUSHO, Reiko KOGA, Takeyuki AKITA, Masashi MITA, Masanobu NAGANO, Tomomi IDE, Tomonori KIMURA, Wolfgang LINDNER, Chiral amino acid metabolomics studies using two/three-dimensional HPLC for the screening of new biomarkers and designing functional foods/beverages,
The 11th International Symposium on Drug Analysis & The 29th International Symposium on Pharmaceutical and Biomedical Analysis (Leuven, Belgium, 2018 September 10)

 

Takeyuki AKITA, Kenji UEKI, Masashi MITA, Kenji HAMASE, Design and development of multi-mode HPLC stationary phases for chiral separation of amino acids and related compounds,
25th International Symposium on Electro-and Liquid Phase-Separation Techniques (Kyoto, 2018 August 31), IN-1.

【招待講演】

 

Kenji HAMASE, Reiko KOGA, Aogu FURUSHO, Chin-Ling HSIEH, Nutchaya SEREEKITTIKUL, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Jen-Ai LEE, Wolfgang LINDNER, Three-dimensional chiral HPLC analysis of amino acids and related compounds in complex biological matrices including human clinical samples,
47
th International Symposium on High Performance Liquid Phase Separations and Related Techniques (Washington, DC, USA, 2018 August 2), P71.

【招待講演】


Reiko KOGA, Ena YANO, Tomoko SHINOJIMA, Masashi MITA, Tomomi IDE, Hideyuki YOSHIDA, Hitoshi NOHTA, Kenji HAMASE, Enantioselective and simultaneous 2D-HPLC determination of citrulline and homocitrulline in human clinical samples,
47th International Symposium on High Performance Liquid Phase Separations and Related Techniques (Washington, DC, USA, 2018 July 31), P191.

Aogu FURUSHO, Reiko KOGA, Takeyuki AKITA, Masashi MITA, Tomonori KIMURA, Kenji HAMASE, Three-dimensional HPLC analysis of chiral amino acids in the plasma of patients with chronic kidney disease,
47
th International Symposium on High Performance Liquid Phase Separations and Related Techniques (Washington, DC, USA, 2018 July 31), P149.

 

Aogu FURUSHO, Reiko KOGA, Takeyuki AKITA, Masashi MITA, Tomonori KIMURA, Kenji HAMASE, Development of a three-dimensional HPLC system and application to the chiral amino acid analysis in the plasma of patients with kidney disfunction,
2018 Sino-Japanese Joint Symposium on Separation Sciences (Dalian, China, July 11-12), P87

 

 
Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Kenji HAMASE, Selective screening of free D-amino acids in the physiological fluids and D-form residues in the proteins using an automated two-dimensional HPLC-MS/MS system,
2018 Sino-Japanese Joint Symposium on Separation Sciences (Dalian, China, July 11-12), P86.


Kenji HAMASE, Multi-dimensional chiral HPLC: A promising approach to expand the frontier of amino acid, peptide and protein research,
2018 Sino-Japanese Joint Symposium on Separation Sciences (Dalian, China, July 12), P53.

【招待講演】


Pitchapa PUTRAKUL, Nutchaya SEREEKITTIKUL, Chiharu ISHII, Panitch BOONSNONGCHEEP, Kenji HAMASE, Benyakan PONGKITWITOON, Development of a microbore reverse-phase HPLC for determination of capsaicinoids in Capsicum extracts,
The 5th International Conference on Current Drug Development 2018 (CDD 2018) and The 3rd International Conference on Herbal and Traditional Medicine 2018 (HTM 2018) (Songkhla, Thailand, 2018 May 23-25), P123.

 

 

Chin-Ling HSIEH, Masashi MITA, Tomomi IDE, Jen-Ai LEE, Kenji HAMASE, Development of a three-dimensional HPLC system with fluorescence detection for the simultaneous determination of lactate and 3-hydroxybutyrate enantiomers in human clinical samples,
XVIII International Symposium on Luminescence Spectrometry (Brest, France, 2018 June 19-22), P31.

 

Kenji HAMASE, Multi-dimensional HPLC with fluorescence detection as a promising method for trace analysis of chiral amino acids and hydroxy acids in clinical, food and extraterrestrial samples,
XVIII International Symposium on Luminescence Spectrometry (Brest, France, 2018 June 20), P14.

【招待講演】

  

Siralak LAORATANAPONG, Nutchaya SEREEKITTIKUL, Kenji UEKI, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Boonchoo SRITULARAK, Kenji HAMASE, Two-dimensional HPLC analysis of Asp-Gly and Gly-Asp enantiomers in human samples and fermented products,
34th International Annual Meeting In Pharmaceutical Sciences & 2nd CU FPHS-RIKEN CDB Symposium,
(Bangkok, Thailand, 2018 March 8-9), P74.

Best Poster Award

Chiharu ISHII, Masashi MITA, Takeyuki AKITA, Tomomi IDE, Kenji HAMASE, Development of a fully automated two-dimensional HPLC-MS/MS system for the determination of amino acid enantiomers in human physiological fluids and fermented beverages,
34th International Annual Meeting In Pharmaceutical Sciences & 2nd CU FPHS-RIKEN CDB Symposium,
(Bangkok, Thailand, 2018 March 8-9), P61.

【招待講演】

 
  2017年

Kenji HAMASE, Takeyuki AKITA, Masashi MITA, Hiroshi NARAOKA, Wolfgang LINDNER, Multi-dimensional chiral HPLC analysis of amino acids in clinical samples and extraterrestrial materials,
The 46
th International Symposium on High Performance Liquid Phase Separations and Related Techniques (Jeju, Korea, 2017 November 9), K39.

【招待講演】

 

Nutchaya SEREEKITTIKUL, Reiko KOGA, Aogu FURUSHO, Roland REISCHL, Masashi MITA, Masanobu NAGANO, Tomomi IDE, Wolfgang LINDNER, Kenji HAMASE, Multi-dimensional HPLC analysis of serine containing chiral depeptides in human physiological fluids and fermented products,
The 46th International Symposium on High Performance Liquid Phase Separations and Related Techniques (Jeju, Korea, 2017 November 7), PT019.

 
Kenta SAKAI, Kenji UEKI, Reiko KOGA, Yurika MIYOSHI, Takeyuki AKITA, Masashi MITA, Ryuichi KONNO, Tomomi IDE, Kenji HAMASE, Development of a two-dimensional chiral HPLC system for leucine structural isomers and determination of their urinary levels,
The 46
th International Symposium on High Performance Liquid Phase Separations and Related Techniques (Jeju, Korea, 2017 November 7), PT017.

Best Poster Award

Aogu FURUSHO, Reiko KOGA, Yurika MIYOSHI, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Kenji HAMASE, Design and development of a three-dimensional HPLC system for chiral amino acid analysis in human clinical samples,
The 46th International Symposium on High Performance Liquid Phase Separations and Related Techniques (Jeju, Korea, 2017 November 6), PM022.

 

Chin-Ling HSIEH, Aogu FURUSHO, Masashi MITA, Tomomi IDE, Jen-Ai LEE, Kenji HAMASE, Enantioselective and simultaneous determination of lactate and 3-hydroxybutyrate in human clinical samples using a narrowbore two-dimensional HPLC system,
The 3rd International Conference of
D-Amino Acid Research (Varese, Italy, 2017 July 10), P63.

 

Kenji HAMASE, Reiko KOGA, Yurika MIYOSHI, Masashi MITA, Jen-Ai LEE, Wolfgang LINDNER, Multi-dimensional HPLC analysis of D-amino acids and related compounds in complicated biological matrices and its clinical applications,
The 3rd International Conference of
D-Amino Acid Research (Varese, Italy, 2017 July 11), P14.

【招待講演】

 

Reiko KOGA, Yu SATO, Masashi MITA, Hiroshi NARAOKA, Kenji HAMASE, Multi-dimensional HPLC analysis of extraterrestrial amino acid enantiomers in various cosmic samples,
The 3rd International Conference of
D-Amino Acid Research (Varese, Italy, 2017 July 10), P6.

【招待講演】

Kenji UEKI, Takeyuki AKITA, Yasuhiko KADOTA, Yasuhiro NISHIO, Yurika MIYOSHI, Masashi MITA, Akio OJIDA, Kenji HAMASE, Development of high resolusion Pirkle-type chiral stationary phases and application to D-amino acid analysis in biological matrices,
45th International Symposium on High Performance Liquid Phase Separations and Related Techniques (Prague, Czech Republic, 2017 June 19), P122.

 

Chiharu ISHII, Tetsuya MIYAMOTO, Shoto ISHIGO, Masashi MITA, Hiroshi HOMMA, Tadashi UEDA, Kenji HAMASE, Accumulation of D-amino acid residues in various proteins during storage,
45
th International Symposium on High Performance Liquid Phase Separations and Related Techniques (Prague, Czech Republic, 2017 June 19), P122.

 
Kenji HAMASE, Reiko KOGA, Yurika MIYOSHI, Masashi MITA, Wolfgang LINDNER, Three-dimensional HPLC analysis of amino acid enantiomers in complicated real world samples,
45
th International Symposium on High Performance Liquid Phase Separations and Related Techniques (Prague, Czech Republic, 2017 June 20), P55.

Kenji HAMASE, Multi-dimensional HPLC analysis of chiral amino acids for drug discovery and diagnosis,
The JSPS-NRCT Follow-Up Seminar 2017 and 33rd International Annual Meeting in Pharmaceutical Sciences (Bangkok, Thailand, 2017 March 2) P61.

【招待講演】


  2016年

Yu SATO, Reiko KOGA, Masashi MITA, Hiroshi NARAOKA, Kenji HAMASE, Enantioselective two-dimensional HPLC determination of α-amino acids in extraterrestrial samples,
XVII International Symposium on Luminescence Spectrometry (Taipei, Taiwan, 2016 November 23), P133.


Reiko KOGA, Yu SATO, Kenji UEKI, Yasuhiko KADOTA, Yasuhiro NISHIO, Masashi MITA, Tomomi IDE, Kenji HAMASE, Design and development of an enansioselective three-dimensional HPLC system for the highly selective fluorescence determination of chiral amino acids,
XVII International Symposium on Luminescence Spectrometry (Taipei, Taiwan, 2016 November 23), P133.

 

Kentaro KOBAYASHI, Yumi IWASHITA, Reiko KOGA, Yurika MIYOSHI, Muneki ISOKAWA, Masashi MITA, Makoto TSUNODA, Tadashi UEDA, Kenji HAMASE, Simultaneous determination of sulfur-containing amino acid stereoisomers using a 2D-HPLC system in the urine of homocystinuria model with cystathionine β-synthase deficiency, XVII International Symposium on Luminescence Spectrometry (Taipei, Taiwan, 2016 November 23), P133. 

Kenji UEKI, Takeyuki AKITA, Yu SATO, Reiko KOGA, Yasuhiko KADOTA, Yasuhiro NISHIO, Yurika MIYOSHI, Masashi MITA, Akio OJIDA, Kenji HAMASE, Design of a novel high resolution Pirkle-type chiral stationary phase and separation of NBD-amino acid enantiomers,
XVII International Symposium on Luminescence Spectrometry (Taipei, Taiwan, 2016 November 23), P133.

 

Yuki MAEDA, Yu,SATO, Reiko KOGA, Yurika MIYOSHI, Yasuhiko KADOTA, Yasuhiro NISHIO, Masashi MITA, Kenji HAMASE, Development of a highly sensitive micro-2D-HPLC system for chiral amino acid metabolomics,
XVII International Symposium on Luminescence Spectrometry, (Taipei, Taiwan, 2016 November 23), P133.

 

Kenji HAMASE, Reiko KOGA, Takeyuki AKITA, Yurika MIYOSHI, Masashi MITA, Hiroshi NARAOKA, Wolfgang LINDNER, Chiral amino acid metabolomics using multi-dimensional HPLC,
XVII International Symposium on Luminescence Spectrometry, (Taipei, Taiwan, 2016 November 24), P62.

【招待講演】

 

Yurika MIYOSHI, Maiko NAKANE, Yoshikazu SUGITO, Yosuke TOJO, Reiko KOGA, Masanobu NAGANO, Masashi MITA, Kenji HAMASE, Two-demensional HPLC-FL determination of chiral amino acids in foodstuffs,
XVII International Symposium on Luminescence Spectrometry (Taipei, Taiwan, 2016 November 23), P35.

【招待講演】

Chiharu ISHII, Shoto ISHIGO, Tetsuya MIYAMOTO, Yurika MIYOSHI, Masashi MITA, Hiroshi HOMMA, Tadashi UEDA, Kenji HAMASE, Determination of D-amino acid residues in proteins stored under various pH conditions,
27th International Symposium on Pharmaceutical and Biomedical Analysis, (Guangzhou, China, 2016 November 14), P.364.

Kenji HAMASE, Reiko KOGA, Yurika MIYOSHI, Masashi MITA, Wolfgang LINDNER, Chiral amino acid analysis: New frontier of drug discovery and diagnosis, 27th International Symposium on Pharmaceutical and Biomedical Analysis (Guangzhou, China, 2016 November 14), P50.

【招待講演】

 
Yuko SAITSU, Yurika MIYOSHI, Yu SATO, Eiichi NEGISHI, Takafumi SUMIYAMA, Masanobu NAGANO, Masashi MITA, Kenji HAMASE, Development of a 2D-HPLC system for NBD-amino acids using a blue LED fluorescence detector and determination of amino acid enantiomers in fermented products,
44th International Symposium on High-Performance Liquid Phase Separations and Related Techniques (San Francisco, CA, USA, 2016 June 23), P229.
 

Reiko KOGA, Yurika MIYOSHI, Yu SATO, Masashi MITA, Ryuichi KONNO, Wolfgang LINDNER, Kenji HAMASE, Enantioselective 2D-HPLC determination of citrulline and ornithine in the urine of D-amino acid oxidase deficient mice,
44th International Symposium on High-Performance Liquid Phase Separations and Related Techniques (San Francisco, CA, USA, 2016 June 21), P105.

 

Kenji HAMASE, Yurika MIYOSHI, Masashi MITA, Wolfgang LINDNER, Chiral amino acid targeted metabolomics as a new strategy for biomarker screening and designing functional foods/beverages,
44th International Symposium on High-Performance Liquid Phase Separations and Related Techniques (San Francisco, CA, USA, 2016 June 23), P55-56.

【招待講演】
  国内学会発表  
  2018年
 

石井千晴,秋田健行,三田真史,井手友美,浜瀬健司,二次元HPLC-MS/MSを用いるD-アミノ酸の高選択的スクリーニング法開発とヒト血漿および尿中含量の解析,
14D-アミノ酸学会学術講演会(富山, 201895日),講演要旨集,P43.

 

吉岡夏輝,酒井健多,秋田健行,三田真史,浜瀬健司,多次元キラルHPLC分析を指向した保持力制御型固定相の開発,
14D-アミノ酸学会学術講演会(富山, 201895日),講演要旨集,P41.

 

高橋美帆,古庄 仰,秋田健行,三田真史,井手友美,浜瀬健司,ヒト臨床試料中における酸性キラルアミノ酸分析を可能とする三次元HPLCシステムの開発,
14D-アミノ酸学会学術講演会(富山, 201895日),講演要旨集,P40.

Po-Yeh LIN, Chin-Ling HSIEH, Shin-Ming CHEN, Chia-En LIN, Chia-Yu LIN, Kenji HAMASE, Jen-Ai LEE, Analysis of 3-hydroxybutyate enantiomers in the urine and serum of mice model of accelerated nephrotoxic serum nephritis,
31回バイオメディカル分析科学シンポジウム(福岡, 2018829日),講演要旨集,P68.

 

 

石井千晴,二次元HPLC-MS/MSを用いる遊離および結合型キラルアミノ酸の精密分析法開発,
36回九州分析化学若手の会夏季セミナー(熊本, 2018728日),講演要旨集,P86.

 

田中優光,酒井健多,秋田健行,三田真史,浜瀬健司,Ile立体異性体を含む疎水性アミノ酸の三次元HPLCキラル識別分析,
36回九州分析化学若手の会夏季セミナー(熊本, 2018728日),講演要旨集,P62.

 

吉岡夏輝,植木健治,秋田健行,三田真史,浜瀬健司,キラルアミノ酸の多次元HPLC分析を指向した親水性アミノ酸含有新規Pirkle型固定相の開発,
36回九州分析化学若手の会夏季セミナー(熊本, 2018728日),講演要旨集,P61.

 

甲斐永美里,古賀鈴依子,坂口洋平,三田真史,井手友美,吉田秀幸,能田 均,浜瀬健司,キヌレニン鏡像異性体を対象とした高選択的二次元HPLC分析法の開発,
36回九州分析化学若手の会夏季セミナー(熊本, 2018728日),講演要旨集,P60.

 

石井千晴,秋田健行,三田真史,井手友美,浜瀬健司,オンライン二次元HPLC-MS/MSシステムを用いるヒト臨床試料中遊離キラルアミノ酸の含量解析,
25回クロマトグラフィーシンポジウム(弘前,2018615日),講演要旨集,P26.

 

 

古賀鈴依子,矢野恵奈,篠島朋子,三田真史,井手友美,吉田秀幸,能田 均,浜瀬健司,二次元HPLCを用いるシトルリン及びホモシトルリン鏡像異性体の一斉分析法開発とヒト尿中含量解析,
25回クロマトグラフィーシンポジウム(弘前,2018615日),講演要旨集,P23.

 
古庄 仰,古賀鈴依子,秋田健行,三田真史,井手友美,木村友則,浜瀬健司,臨床試料におけるキラルアミノ酸高精度分析を可能とする選択的三次元HPLC法の開発,
25回クロマトグラフィーシンポジウム(弘前,2018614日),講演要旨集,P58.

【優秀発表賞】

 

田中優光,酒井健多,秋田健行,三田真史,浜瀬健司,多次元キラルHPLCを用いる疎水性アミノ酸精密分析法の開発,
日本薬学会第
138年会,(金沢,2018328日),講演要旨集,28V-pm02.

佐藤根詩織,岩下裕美,秋田健行,三田真史,井手友美,浜瀬健司,含硫アミノ酸光学異性体の多次元HPLC分析法開発とヒト血漿および尿における含量解析,
日本薬学会第
138年会,(金沢,2018328日),講演要旨集,28V-pm01. 

二井屋田美樹,吉田あすみ,秋田健行,三田真史,浜瀬健司,新規蛍光誘導体化試薬NBD-COOSuを用いる親水性アミノ酸の二次元キラルHPLC分析法開発,
日本薬学会第
138年会,(金沢,2018328日),講演要旨集,28V-am10.
  
吉岡夏輝,植木健治,秋田健行,三田真史,浜瀬健司,親水性アミノ酸を有する新規Pirkle型キラル固定相の開発とNBD-アミノ酸の分離挙動解析,
日本薬学会第
138年会,(金沢,2018328日),講演要旨集,28V-am07 

  2017年
 筒井佑紀,石井千晴,石郷翔人,根岸栄一,三田真史,秋田健行,植田 正,浜瀬健司,二次元キラルHPLC-MS/MSを用いるタンパク質中の微量アスパラギン/アスパラギン酸残基識別分析法開発,
28回クロマトグラフィー科学会議(京都,20171116日),講演要旨集,P53.

【優秀発表賞】

 

伊豆拓真,古賀鈴依子,秋田健行,門田靖彦,西尾康弘,三田真史,井手友美,浜瀬健司,芳香族アミノ酸をキラルセレクターに有する新規パークル型キラル固定相のデザインとヒト臨床試料の二次元HPLC分析,
28回クロマトグラフィー科学会議(京都,20171117日),講演要旨集,P52.

小川亜都美,三次百合香,木村友則,三田真史,秋田健行,猪阪善隆,浜瀬健司,キラルアミノ酸の高選択的二次元HPLC-MS分析法開発と哺乳類体内D-アミノ酸の由来および疾患に伴う含量変化解析,
28回クロマトグラフィー科学会議(京都,20171116日),講演要旨集,P51.

高橋美帆,古庄 仰,三田真史,秋田健行,井手友美,浜瀬健司,高分離能多次元HPLCを利用する親水性アミノ酸鏡像異性体の分析,
28回クロマトグラフィー科学会議(京都,20171117日),講演要旨集,P29.

 

浜瀬健司,多次元HPLCによるキラルアミノ酸・ヒドロキシ酸分析とアプリケーション,
日本分析化学会第
66年会(東京,2017910日),講演要旨集,P118.

【招待講演】

 

酒井健多,植木健治,古賀鈴依子,三次百合香,秋田健行,三田真史,金野柳一,浜瀬健司,ロイシン構造異性体の二次元キラルHPLC一斉分析法開発とD-アミノ酸酸化酵素欠損に伴う尿中含量変化の解析,
30回バイオメディカル分析科学シンポジウム(東京,2017828日),講演要旨集,P67.

 

古庄 仰,古賀鈴依子,秋田健行,三次百合香,三田真史,浜瀬健司,カラム内径比を制御した新規高感度型二次元HPLCの開発・評価と哺乳類組織中キラルアミノ酸分析への適用,
30回バイオメディカル分析科学シンポジウム(東京,2017828日),講演要旨集,P66.

Bing ZHAO, Takeyuki AKITA, Aogu FURUSHO, Masashi MITA, Kenji HAMASE, Characterization of NBD-amino acids with low fluorescence intensities and application to enantioselective HPLC analysis,
35回九州分析化学若手の会夏季セミナー(朝倉,2017728日),講演要旨集,P57.

 

古庄 仰,古賀鈴依子,秋田健行,三次百合香,三田真史,浜瀬健司,カラム内径比を制御した新規高感度型二次元キラルHPLC分析装置の開発と脳内D-アミノ酸含量の解析,
35回九州分析化学若手の会夏季セミナー(朝倉,2017728日),講演要旨集,P56.

【九州分析化学若手賞】

 
酒井健多,植木健治,古賀鈴依子,秋田健行,三次百合香,三田真史,井手友美,浜瀬健司,ロイシン構造異性体α-キラルアミノ酸を対象とした二次元HPLC一斉分析法の開発とヒト尿中含量の解析,
35回九州分析化学若手の会夏季セミナー(朝倉,2017728日),講演要旨集,P55.

Nutchaya SEREEKITTIKUL, Reiko KOGA, Aogu FURUSHO, Roland REISCHL, Masashi MITA, Wolfgang LINDNER, Kenji HAMASE, Development of the multi-dimensional HPLC system for serine containing chiral dipeptides and application to clinical/food samples,
35回九州分析化学若手の会夏季セミナー(朝倉,2017728日),講演要旨集,P54.

Chin-Ling HSIEH, Aogu FURUSHO, Masashi MITA, Tomomi IDE, Jen-Ai LEE, Kenji HAMASE, Development of a two-dimensional HPLC system for the simultaneous determination of lactate and 3-hydroxybutyrate enantiomers in biological matrices including human clinical samples,
24回クロマトグラフィーシンポジウム(仙台,2017615日),講演要旨集,P14.

【優秀発表賞】
 

植木健治,秋田健行,門田靖彦,西尾康弘,三田真史,浜瀬健司,新規Pirkle型キラル固定相の設計・作製とNBD-アミノ酸/ジペプチドの分離特性解析,
24回クロマトグラフィーシンポジウム(仙台,2017615日),講演要旨集,P13.

 

浜瀬健司,多次元HPLCによるキラルアミノ酸分析と医療応用,
77回分析化学討論会(京都,2017528日),講演要旨集,P42.

【招待講演】

 

吉田あすみ,秋田健行,古賀鈴依子,植木健治,佐藤 裕,三田真史,浜瀬健司,トリプトファンNBD誘導体の高感度蛍光キラルHPLC分析法開発,
日本薬学会第
137年会(仙台,2017325日),講演要旨集,25P-pm05.

上村将平,石井千晴,石郷翔人,三田真史,植田 正,浜瀬健司,重塩酸加水分解・二次元キラルHPLC-MS/MSを用いる分岐鎖D-アミノ酸残基の微量分析,
日本薬学会第
137年会(仙台,2017325日),講演要旨集,25P-pm04.

古庄 仰,前田佑樹,植木健治,佐藤 裕,古賀鈴依子,三次百合香,三田真史,浜瀬健司,カラム内径比を制御した新規高感度型二次元キラルHPLC分析装置の開発,
日本薬学会第
137年会(仙台,2017325日),講演要旨集,25P-pm03.

岩下裕美,小林健太郎,古賀鈴依子,三次百合香,三田真史,植田 正,浜瀬健司,ホモシステイン-システイン混合ジスルフィドの二次元キラルHPLC分析法開発,
日本薬学会第
137年会(仙台,2017325日),講演要旨集,25P-pm02.

 
酒井健多,植木健治,佐藤 裕,古賀鈴依子,三次百合香,三田真史,浜瀬健司,ロイシン構造異性体の二次元キラルHPLC一斉分析法開発,
日本薬学会第
137年会(仙台,2017325日),講演要旨集,25P-pm01.

  2016年

Nutchaya SEREEKITTIKUL, Karen Naomi IKEJIRI, Aogu FURUSHO, Reiko KOGA, Roland REISCHL, Masashi MITA, Wolfgang LINDNER, Kenji HAMASE, Two-dimensional HPLC analysis of serine containing chiral peptides,
27回クロマトグラフィー科学会議(東京,20161118日),講演要旨集,P84.

 

Karen Naomi IKEJIRI, Reiko KOGA, Aogu FURUSHO, Masashi MITA, Kenji HAMASE, Development of a 2D-HPLC system for enantioselective determination of chiral dipeptides containing alanine,
27回クロマトグラフィー科学会議(東京,20161117日),講演要旨集,P83.

 

古賀鈴依子,佐藤 裕,植木健治,門田靖彦,西尾康弘,三田真史,井手友美,浜瀬健司,三次元HPLCを用いる生体内微量キラルアミノ酸の高選択的分析法開発,
27回クロマトグラフィー科学会議(東京,20161117日),講演要旨集,P26.

 

石井千晴,石郷翔人,宮本哲也,三次百合香,三田真史,本間 浩,植田 正,浜瀬健司,種々のタンパク質におけるD-アミノ酸残基の微量分析と保存による含量増加,
27回クロマトグラフィー科学会議(東京,20161117日),講演要旨集,P25.

 

浜瀬健司,キラルアミノ酸分析が拓く未来の医療,
47回中部化学関係学協会支部連合秋季大会(豊橋,2016115日),講演要旨集,P42.

【招待講演】 

佐藤 裕,中内佑亮,古賀鈴依子,三次百合香,三田真史,奈良岡 浩,浜瀬健司,二次元キラルHPLCによる宇宙アミノ酸の分析,
新アミノ酸分析研究会第
6回学術講演会(東京,2016114日),講演要旨集,P25.

 

 

佐藤 裕,古賀鈴依子,三田真史,奈良岡 浩,浜瀬健司,二次元キラルHPLCを用いる地球外試料中のα-アミノ酸分析法開発,
12D-アミノ酸学会学術講演会(高知,2016914日),講演要旨集,P64.

 

 

浜瀬健司,古賀鈴依子,三次百合香,三田真史,奈良岡 浩,多次元分析による生体・食品・宇宙試料中のキラルアミノ酸精密定量,
12D-アミノ酸学会学術講演会(高知,2016914日),講演要旨集,P41.

 

小林健太郎,横井佐智,古賀鈴依子,三次百合香,磯川宗生,三田真史,角田 誠,植田 正,浜瀬健司,二次元HPLCを用いる含硫アミノ酸光学異性体の一斉分析法開発,
29回バイオメディカル分析科学シンポジウム(京都,201692日),講演要旨集,P82. 

 

伊豆拓真,植木健治,佐藤 裕,古賀鈴依子,三次百合香,門田靖彦,西尾康弘,三田真史,浜瀬健司,芳香族アミノ酸をキラルセレクターに有する新規パークル型キラル固定相の開発とNBD-アミノ酸の光学分割,
29回バイオメディカル分析科学シンポジウム(京都,201692日),講演要旨集,P53.

浜瀬健司,多次元HPLCを用いるキラルアミノ酸メタボロミクスによる創薬・診断・機能性プロダクト開発,
29回バイオメディカル分析科学シンポジウム(京都,201693日),講演要旨集,P45.

【招待講演】

石井千晴,石郷翔人,宮本哲也,三次百合香,三田真史,本間 浩,植田 正,浜瀬健司,タンパク質保存時におけるD-アミノ酸残基の生成,
34回九州分析化学若手の会夏季セミナー(日田,2016729日),講演要旨集,P60.

 

植木健治,佐藤 裕,古賀鈴依子,三次百合香,門田靖彦,西尾康弘,三田真史,王子田彰夫,浜瀬健司,高分離能パークル型キラル固定相のデザインとNBD-アミノ酸の光学分割能評価,
34回九州分析化学若手の会夏季セミナー(日田,2016729日),講演要旨集,P59.

【九州分析化学若手賞】

 

Yu-Chun CHIU, Jen-Ai LEE, Shih-Ming CHEN, Yurika MIYOSHI, Yu SATO, Masashi MITA, Masanobu NAGANO, Tomomi IDE, Kenji HAMASE, Simultaneous determination of lactate and 3-hydroxybutyrate enantiomers using a 2D-HPLC system with various Pirkle-type columns,
23回クロマトグラフィーシンポジウム(甲府,2016617日),講演要旨集,P48.

石井千晴,石郷翔人,三次百合香,宮本哲也,三田真史,本間 浩,植田 正,浜瀬健司,種々の条件で保存したOvalbuminにおけるD-アミノ酸残基の生成解析,
23回クロマトグラフィーシンポジウム(甲府,2016616日),講演要旨集,P39.

【ポスター賞】

石郷翔人,佐藤 裕,三次百合香,三田真史,植田 正,浜瀬健司,D-アミノ酸残基網羅的定量を目的とした重塩酸加水分解・二次元HPLC-MS/MS分析法の開発,
23回クロマトグラフィーシンポジウム(甲府,2016617日),講演要旨集,P19.
 

植木健治,佐藤 裕,三次百合香,門田靖彦,西尾康弘,三田真史,王子田彰夫,浜瀬健司,高分離能を有する新規パークル型キラル固定相の作製とNBD-アミノ酸の光学分割,
23回クロマトグラフィーシンポジウム(甲府,2016616日),講演要旨集,P8.

筒井佑紀,石郷翔人,佐藤 裕,三次百合香,根岸栄一,三田真史,植田 正,浜瀬健司,タンパク質中のアスパラギン/アスパラギン酸残基識別を可能とする二次元キラルHPLC-MS/MS分析法開発,
日本薬学会第
136年会(横浜,2016327日),講演要旨集,27L-am14.

 

小川亜都美,三次百合香,佐藤 裕,三田真史,浜瀬健司,二次元HPLCを用いる尿中キラルアミノ酸の由来および含量変化解析,
日本薬学会第
136年会(横浜,2016327日),講演要旨集,27L-am13.

  

寺尾 唯,小川亜都美,三次百合香,佐藤 裕,長野正信,三田真史,浜瀬健司,二次元HPLC-MSを用いるNBD-アミノ酸光学異性体の高選択的分析法開発,
日本薬学会第
136年会(横浜,2016327日),講演要旨集,27L-am12.

 

浜瀬健司,キラルアミノ酸分析が生み出す新たな世界−医療・食品・宇宙への展開−,
日本薬学会近畿支部平成
28年新春特別講演会(京都,201618日).

【招待講演】