Graduate School of Pharmaceutical Sciences, Kyushu University
Drug Discovery and Evolution
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 2013-2015
 Research Paper in English
  2015

Shu-Ling LIU, Tsubasa OYAMA, Yurika MIYOSHI, Shiow-Yunn SHEU, Masashi MITA, Tomomi IDE, Wolfgang LINDNER, Kenji HAMASE, Jen-Ai LEE, Establishment of a two-dimensional chiral HPLC system for the simultaneous detection of lactate and 3-hydroxybutyrate enantiomers in human clinical samples,
Journal of Pharmaceutical and Biomedical Analysis, 116, 80-85 (2015). DOI:10.1016/j.jpba.2015.05.036

 

Tsubasa OYAMA, Eiichi NEGISHI, Hirohisa ONIGAHARA, Nao KUSANO, Yurika MIYOSHI, Masashi MITA, Manabu NAKAZONO, Sumio OHTSUKI, Akio OJIDA, Wolfgang LINDNER, Kenji HAMASE, Design and synthesis of a novel pre-column derivatization reagent with a 6-methoxy-4-quinolone moiety for fluorescence and tandem mass spectrometric detection and its application to chiral amino acid analysis,
Journal of Pharmaceutical and Biomedical Analysis,116,71-79(2015)
. DOI:10.1016/j.jpba.2015.05.039

Hai HAN, Yurika MIYOSHI, Reiko KOGA, Masashi MITA, Ryuichi KONNO, Kenji HAMASE, Changes in D-aspartic acid and D-glutamic acid levels in the tissues and physiological fluids of mice with various D-aspartate oxidase activities,
Journal of Pharmaceutical and Biomedical Analysis, 116, 47-52 (2015). DOI:10.1016/j.jpba.2015.05.013


Tsubasa OYAMA, Rie NAGAI, Mayumi FUJIMOTO, Ryoko KONISHI, Masashi MITA, Keiko UEZONO, Kiyoshi ZAITSU, Kenji HAMASE, Development of a fully-automated on-line oxidation column-switching HPLC system for the determination of endogenous melatonin in human clinical samples,
Analytical Sciences
, 31(11),1129-1135(2015).
 DOI10.2116/analsci.31.1129

Sachise KARAKAWA, Kazutaka SHIMBO, Naoyuki YAMADA, Toshimi MIZUKOSHI, Hiroshi MIYANO, Masashi MITA, Wolfgang LINDNER, Kenji HAMASE, Simultaneous analysis of D-alanine, D-aspartic acid, and D-serine using chiral high-performance liquid chromatography-tandem mass spectrometry and its application to the rat plasma and tissues,
Journal of Pharmaceutical and Biomedical Analysis, 115,123-129,(2015).
DOI:10.1016/j.jpba.2015.05.024
 

Shoto ISHIGO, Eiichi NEGISHI, Yurika MIYOSHI, Hirohisa ONIGAHARA, Masashi MITA, Tetsuya MIYAMOTO, Haruhiko MASAKI, Hiroshi HOMMA, Tadashi UEDA, Kenji HAMASE, Establishment of a two-dimensional HPLC-MS/MS method combined with DC1/D2O hydrolysis for the determination of trace amounts of D-amino acid residues in proteins,
Chromatography, 36, 45-50 (2015). DOI:10.15583/jpchrom.2015.017


Masataka SUZUKI, Jumpei SASABE, Yurika MIYOSHI, Kenji HAMASE, Masaaki MATSUOKA, Nobuaki IMANISHI, Sadakazu AISO, Glycolytic flux controls D-serine synthesis through glyceraldehyde-3-phosphate dehydrogenase in astrocytes,
Proceedings of the National Academy of Sciences of the United States of America
, 112, E2217-2224 (2015). DOI: 10.1073/pnas.1416117112
 
Printip WONGTHAI, Kohei HAGIWARA, Yurika MIYOSHI, Pattama WIRIYASERMKUL, Ling WEI, Ryuichi OHGAKI, Itsuro KATO, Kenji HAMASE, Shushi NAGAMORI, Yoshikatsu KANAI, Boronophenylalanine, a boron delivery agent for boron neutron capture therapy, is transported by ATB0, +, LAT1 and LAT2,
Cancer Science
,
106, 279-286 (2015). DOI: 10.1111/cas.12602

Hiroshi HAMAMOTO, Makoto URAI, Kenichi ISHII, Jyunichiro YASUKAWA, Atmika PAUDEL, Motoki MURAI, Takuya KAJI, Takefumi KURANAGA, Kenji HAMASE, Takashi KATSU, Jie SU, Tatsuo ADACHI, Ryuji UCHIDA, Hiroshi TOMODA, Maki YAMADA, Manabu SOUMA, Hiroki KURIHARA, Masayuki INOUE, Kazuhisa SEKIMIZU, Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane,
Nature Chemical Biology, 11, 127-133 (2015). DOI:10.1038/nchembio.1710
 

Takato ABE, Masataka SUZUKI, Jumpei SASABE, Shinichi TAKAHASHI, Miyuki UNEKAWA, Kyoko MASHIMA, Takuya IIZUMI, Kenji HAMASE, Ryuichi KONNO, Sadakazu AISO, Norihiro SUZUKI, Cellular origin and regulation of D- and L-serine in in vitro and in vivo models of cerebral ischemia,
Journal of Cerebral Blood Flow and Metabolism
,
 34, 1928-1935 (2014). DOI: 10.1038/jcbfm.2014.164
  2014
Kenji HAMASE, Yusuke NAKAUCHI, Yurika MIYOSHI, Reiko KOGA, Nao KUSANO, Hirohisa ONIGAHARA, Hiroshi NARAOKA, Hajime MITA, Yasuhiko KADOTA, Yasuhiro NISHIO, Masashi MITA, Wolfgang LINDNER, Enantioselective determination of extraterrestrial amino acids using a two-dimentional chiral high-performance liquid chromatographic system,
Chromatography, 35,103-110 (2014). DOI:10.15583/jpchom.2014.014

Yurika MIYOSHI, Masanobu NAGANO, Shoto ISHIGO, Yusuke ITO, Kazunori HASHIGUCHI, Naoto HISHIDA, Masashi MITA, Wolfgang LINDNER, Kenji HAMASE, Chiral amino acid analysis of Japanese traditional Kurozu and the developmental changes during earthenware jar fermentation processes,
Journal of Chromatography B
, 966,187-192 (2014). DOI:10.1016/j.jchromb.2014.01.034

Ran INOUE, Yoko YOSHIHISA, Yosuke TOJO, Chieko OKAMURA, Yuzo YOSHIDA, Jiro KISHIMOTO, Xinghua LUAN, Masahiko WATANABE, Mineyuki MIZUGUCHI, Yuko NABESHIMA, Kenji HAMASE, Kenji MATSUNAGA, Tadamichi SHIMIZU, Hisashi MORI, Localization of serine racemase and its role in the skin,
Journal of Investigative Dermatology, 134,1618-1626 (2014).
DOI:10.1038/jid.2014.22
Jumpei SASABE, Masataka SUZUKI, Yurika MIYOSHI, Yosuke TOJO, Chieko OKAMURA, Sonomi ITO, Ryuichi KONNO, Masashi MITA, Kenji HAMASE, Sadakazu AISO. Ischemic acute kidney injury perturbs homeostasis of serine enantiomers in the body fluid in mice: early detection of renal dysfunction using the ratio of serine enantiomers.
PLOS ONE. 9.e86504 (2014) . DOI:10.1371/journal.pone.0086504
  2013
Sachise KARAKAWA, Yurika MIYOSHI, Ryuichi KONNO, Satoru KOYANAGI, Masashi MITA, shigehiro OHDO, Kenji HAMASE. Two-dimensional high -performance liquid chromatographic determination of day-night variation of D-alanine in mammals and factors controlling the circadian changes.
Analytical and Bioanalytical Chemistry.405.8083-8091 (2013). DOI:10.1007/s00216-013-7071-2

 Review in English
  2014
Yurika MIYOSHI, Tsubasa OYAMA, Yusuke ITOH, Kenji HAMASE, Enantioselective two-dimensional high-performance liquid chromatographic determination of amino acids; analysis and physiological significance of D-amino acids in mammals Chromatography, 35, 49-57 (2014). DOI:10.15583/jpchrom.2014.005.
 
  International Conference  
  2015
Yurika MIYOSHI, Jumpei SASABE, Masataka SUZUKI, Yayoi YONENAGA, Yu SATO, Maiko NAKANE, Masashi MITA, Sadakazu AISO, Kenji HAMASE, Two-dimensional HPLC-FL/MS/MS determination of chiral amino acids in physiological fluids of model mice of ischemic acute kidney injury,
26th International Symposium on Pharmaceutical and Biomedical Analysis, (Tbilisi, Georgia, 2015 July), P166.
 

Kenji HAMASE, Yurika MIYOSHI, Masashi MITA, Wolfgang LINDNER, Chiral amino acid metabolomics for drug discovery, clinical diagnosis and designing functional foods/ beverages,
26th International Symposium on Pharmaceutical and Biomedical Analysis, (Tbilisi, Georgia, 2015 July), P25.

 

Reiko KOGA, Yurika MIYOSHI, Hirohisa ONIGAHARA, Masashi MITA, Ryuichi KONNO, Wolfgang LINDNER, Kenji HAMASE, Enantioselective determination of phenylalanine, tyrosine and 3,4-dihydroxyphenylalanine in the model mice with metabolic disorders,
42nd
International Symposium on High Performance Liquid Phase Separations and Related Techniques, (Geneva, Switzerland, 2015 June), P314.

 
Shoto ISHIGO, Eiichi NEGISHI, Yurika MIYOSHI, Hirohisa ONIGAHARA, Masashi MITA, Tadashi UEDA, Kenji HAMASE, Determination of trace levels of D-Asp and D-Glu residues in proteins using a two-dimensional HPLC-MS/MS system,
42nd
International Symposium on High Performance Liquid Phase Separations and Related Techniques, (Geneva, Switzerland, 2015 June), P313.
 

Kenji HAMASE, Yurika MIYOSHI, Yayoi YONENAGA, Hirohisa ONIGAHARA, Yusuke ITO, Masashi MITA, Jumpei SASABE, Sadakazu AISO, Wolfgang LINDNER, Chiral amino acid targeted metabolomics for clinical diagnosis using enantioselective two-dimensional HPLC tandem-mass spectrometry,
42nd International Symposium on High Performance Liquid Phase Separations and Related Techniques, (Geneva, Switzerland, 2015 June), P42.

 
Ryosuke MATSUKANE, Tsukasa SHIMAUCHI, Akiyuki NISHIMURA, Takuro TOMITA, Motohiro NISHIDA, Improvement of peripheral arterial disease by a novel TRPC3/6-selective inhibitor,
TRPs and SOCs ~Unconventional Ca2+ Physioligy~ (Okazaki,2015 June), P12.


  2014

Shoto ISHIGO, Reina FUJITA, Yurika MIYOSHI, Eiichi NEGISHI, Hirohisa ONIGAHARA, Masashi MITA, Tetsuya MIYAMOTO, Haruhiko MASAKI, Hiroshi HOMMA, Tadashi UEDA, Kenji HAMASE, Determination of trace amounts of D-amino acid residues in proteins using a two-dimensional chiral HPLC-MS/MS system,
Molecular Chirality Asia 2014 (Beijing, China, 2014 October), P91.

 

Kenji HAMASE, Chiral amino acid metabolomics for clinical diagnosis,
Molecular Chirality Asia 2014 (Beijing, China, 2014 October), P48.


Tsubasa OYAMA, Eiichi NEGISHI, Nao KUSANO, Hirohisa ONIGAHARA, Yurika MIYOSHI, Masashi MITA, Sumio OHTSUKI, Akio OJIDA, Wolfgang LINDNER, Kenji HAMASE, Development of a 2D-HPLC system for chiral amino acid analysis using a novel FL/MS/MS reagent with 6-methoxy-4-quinolone moiety,
30th International Symposium on Chromatography (Salzburg, Austria, 2014 September), P536.

Hirohisa ONIGAHARA, Nao KUSANO, Yurika MIYOSHI, Yasuhiko KADOTA, Yasuhiro NISHIO, Masashi MITA, Akio OJIDA, Wolfgang LINDNER, Kenji HAMASE, Design and development of novel high-performance Pirkle-type stationary phases for chiral amino acid metabolomics studies,
30th International Symposium on Chromatography (Salzburg, Austria, 2014 September), P535.

 

Yurika MIYOSHI, Nao KUSANO, Yayoi YONENAGA, Hirohisa ONIGAHARA, Jumpei SASABE, Eiichi NEGISHI, Maiko NAKANE, Masashi MITA, Tomonori KIMURA, Ryohei YAMAMOTO, Yoshitaka ISAKA, Sadakazu AISO, Kenji HAMASE, Enantioselective determination of all proteinogenic amino acids in the serum and urine of patients/mice with renal dysfunction using a two-dimensional HPLC-FL/MS/MS system,
30th International Symposium on Chromatography (Salzburg, Austria, 2014 September), P534.

 
Sachi YOKOI, Yurika MIYOSHI, Eiichi NEGISHI, Masashi MITA, Tadashi UEDA, Kenji HAMASE, Development of a two-dimensional chiral HPLC system for the simultaneous determination of cystine isomers,
30th International Symposium on Chromatography (Salzburg, Austria, 2014 September), P512.
 

Kenji HAMASE, Yurika MIYOSHI, Jumpei SASABE, Tomonori KIMURA, Masashi MITA, Ryohei YAMAMOTO, Yoshitaka ISAKA, Sadakazu AISO, Wolfgang LINDNER, Chiral amino acid metabolomics using two-dimensional HPLC for novel biomarker screening,
30th International Symposium on Chromatography (Salzburg, Austria, 2014 September), OR44.

Yayoi YONENAGA, Yurika MIYOSHI, Hirohisa ONIGAHARA, Eiichi NEGISHI, Masashi MITA, Jumpei SASABE, Sadakazu AISO, Kenji HAMASE, Chiral amino acid metabolomics of human urine using two-dimensional high-performance liquid chromatography,
The 2nd International Conference of D-Amino Acid Research (Utsunomiya, Japan, 2014 September), P87.
 

Yurika MIYOSHI, Eiichi NEGISHI, Masanobu NAGANO, Jumpei SASABE, Maiko NAKANE, Masashi MITA, Ryuichi KONNO, Sadakazu AISO, Kenji HAMASE, Chiral amino acid metabolomics using two-dimensional HPLC focusing on neuro-active amino acids,
The 2nd International Conference of D-Amino Acid Research (Utsunomiya, Japan, 2014 September), P65.

 
Hirohisa ONIGAHARA, Nao KUSANO, Yurika MIYOSHI, Yasuhiko KADOTA, Yasuhiro NISHIO, Masashi MITA, Akio OJIDA, Wolfgang LINDNER, Kenji HAMASE, Development of novel high-performance Pirkle-type chiral stationary phases having branched aliphatic amino acids
The 2nd International Conference of D-Amino Acid
Research (Utsunomiya, Japan, 2014 September), P62.

 
Reiko KOGA, Yurika MIYOSHI, Hirohisa ONIGAHARA, Masashi MITA, Wolfgang LINDNER, Kenji HAMASE, Establishment of a 2D-HPLC system for the enantioselective determination of aromatic amino acids
The 2nd International Conference of D-Amino Acid Research (Utsunomiya, Japan, 2014 September), P61.
 
Tsubasa OYAMA, Eiichi NEGISHI, Hirohisa ONIGAHARA, Yurika MIYOSHI, Masashi MITA, Sumio OHTSUKI, Akio OJIDA, Wolfgang LINDNER, Kenji HAMASE, Establishment of a 2D-HPLC system for chiral amino acid metabolomics using a novel FL/MS/MS reagent with 6-methoxy-4-quinolone moiety and its deuterated analog
The 2nd International Conference of D-Amino Acid Research (Utsunomiya, Japan, 2014 September), P26

 
Shoto ISHIGO, Reina FUJITA, Yurika MIYOSHI, Eiichi NEGISHI, Hirohisa ONIGAHARA, Masashi MITA, Tetsuya MIYAMOTO, Haruhiko MASAKI, Hiroshi HOMMA, Tadashi UEDA, Kenji HAMASE, Establishment of a two-dimensional chiral HPLC-MS/MS system for the determination of trace amounts of D-amino acid residues in proteins The 2nd International Conference of D-Amino Acid Research (Utsunomiya, Japan, 2014 September), P20.


Kenji HAMASE, Yurika MIYOSHI, Tomonori KIMURA, Jumpei SASABE, Nao KUSANO, Hirohisa ONIGAHARA, Masashi MITA, Ryohei YAMAMOTO, Yoshitaka ISAKA, Sadakazu AISO, Wolfgang LINDNER, Chiral Amino Acid Metabolomics for  the Diagnosis of Renal Disorders Using an Enantioselective 2D-HPLC-FL/MS/MS System
41st International Symposium on High Performance Liquid Phase Separations and Related Techniques (New Orleans, LA, USA, 2014, May), L-058.

 

  2013
Yurika MIYOSHI, Masanobu NAGANO, Yusuke ITO, Shoto ISHIGO, Kazunori HASHIGUCHI, Naoto HISHIDA, Eiichi NEGISHI, Maiko NAKANE, Masashi MITA, Kenji HAMASE, Determination of D-amino acids in the Japanese traditional amber rice vinegar “Kurozu” by using a 2D-HPLC-FL/MS/MS system
40th International Symposium on High-Performance Liquid Phase Separations and Related Techniques (Hobart, Australia, 2013 Nobember), P95-96.
 

Kenji HAMASE, Yusuke ITO, Hirohisa ONIGAHARA, Nao KUSANO, Yurika MIYOSHI, Masashi MITA, Wolfgang LINDNER, Chiral amino acid metabolomics for the sensitive diagnosis of metabolic disorders
40th International Symposium on High-Performance Liquid Phase Separations and Related Techniques (Hobart, Australia, 2013 Nobember), P49-50.

Tsubasa OYAMA, Eiichi NEGISHI, Nao KUSANO, Hirohisa ONIGAHARA, Yurika MIYOSHI, Masashi MITA, Manabu NAKAZONO, Sumio OHTSUKI, Akio OJIDA, Wolfgang LINDNER, Kenji HAMASE, Design and synthesis of a novel reagent with 6-MOQ moiety for amino acid labeling and chiral separations of all proteinogenic amino acids
39th International Symposium on High-Performance Liquid Phase Separations and Related Techniques (Amsterdam, The Netherlands, 2013 June), P287.
 

Nao KUSANO, Jumpei SASABE, Hirohisa ONIGAHARA, Yurika MIYOSHI, Masashi MITA, Sadakazu AISO, Wolfgang LINDNER, Kenji HAMASE, Simultaneous two-dimensional high-performance liquid chromatographic determination of all proteinogenic amino acid enantiomers in human serum using high performance Pirkle-type chiral stationary phases
39th International Symposium on High-Performance Liquid Phase Separations and Related Techniques (Amsterdam, The Netherlands, 2013 June), P285.
 

Kenji HAMASE, Yurika MIYOSHI, Nao KUSANO, Jumpei SASABE, Yosuke TOJO, Masashi MITA, Sadakazu AISO, Wolfgang LINDNER, Chiral amino acid metabolome analysis for biomarker assay in clinical diagnosis using enantioselective 2D-HPLC
39th International Symposium on High-Performance Liquid Phase Separations and Related Techniques (Amsterdam, The Netherlands, 2013 June), P63.

 
Chieko OKAMURA, Yosuke TOJO, Kayo MATSUMOTO, Junichi HOSOI, Kenji HAMASE, Jiro KISHIMOTO, Free D-amino acid as a candidate for the intrinsic multi-functional molecule in the skin
11th Asian Scieties of Cosmetic Scientists Conference (Sanur, Bali-Indonesia, 2013 April), Abstract book, p.42.