Graduate School of Pharmaceutical Sciences, Kyushu University
Drug Discovery and Evolution
                              日本語ENGLISH
本文へジャンプ
      
2013-2014
 Research Paper in English
  2017

Chiharu ISHII, Tetsuya MIYAMOTO, Shoto ISHIGO, Yurika MIYOSHI, Masashi MITA, Hiroshi HOMMA, Tadashi UEDA, Kenji HAMASE, Two-dimensional HPLC-MS/MS determination of multiple D-amino acid residues in the proteins stored under various pH conditions,
Chromatography
, 38, 65-72 (2017), DOI:10.15583/jpchrom.2017.009

 

Akiko MORIKAWA, Hideoki FUKUOKA, Keiko UEZONO, Masashi MITA, Satoru KOYANAGI, Shigehiro OHDO, Kiyoshi ZAITSU, Kenji HAMASE, Sleep-awake profile related circadian D-alanine rhythm in human serum and urine, Chromatography, 38,53-58(2017), DOI:10.15583/jpchrom.2017.003

 

Makoto ARIYOSHI, Masumi KATANE, Kenji HAMASE, Yurika MIYOSHI, Maiko NAKANE, Atsushi HOSHINO, Yoshifumi OKAWA, Yuichiro MITA, Satoshi KAIMOTO, Motoki UCHIHASHI, Kuniyoshi FUKAI, Kazunori ONO, Syuhei TATEISHI, Daichi HATO, Ryoetsu YAMANAKA, Sakiko HONDA, Yohei FUSHIMURA, Eri IWAI-KANAI, Naotada ISHIHARA, Masashi MITA, Hiroshi HOMMA, Satoaki MATOBA, D-Glutamate is metabolized in the heart mitochondria,
Scientific Reports,7, 43911 (2017), DOI:10.1038/srep43911

 
  2016

Muneki ISOKAWA, Kentaro KOBAYASHI, Yurika MIYOSHI, Masashi MITA, Takashi FUNATSU, Kenji HAMASE, Makoto TSUNODA, Quantification of biological thiols in the plasma of a homocystinuria model with cystathionine β-synthase deficiency utilizing hydrophilic interaction liquid chromatography and fluorescence detection,
Chromatography, 37, 147-151 (2016), DOI:10.15583/jpchrom.2016.015


Reiko KOGA, Yurika MIYOSHI, Yu SATO, Masashi MITA, Ryuichi KONNO, Wolfgang LINDNER, Kenji HAMASE, Enantioselective determination of citrulline and ornithine in the urine of D-amino acid oxidase deficient mice using a two-dimensional high-performance liquid chromatographic system,
Journal of Chromatography A
, 1467, 312-317 (2016), DOI:10.1016/j.chroma.2016.07.053

 

Jumpei SASABE, Yurika MIYOSHI, Seth Rakoff-NAHOUM, Ting ZHANG, Masashi MITA, Brigid M. DAVIS, Kenji HAMASE, Matthew K. WALDOR, Interplay between microbial D-amino acids and host D-amino acid oxidase modifies murine mucosal defence and gut microbiota,
Nature Microbiology, 1, 16125, (2016), DOI:10.1038/nmicrobiol.2016.125


Tomonori KIMURA, Kenji HAMASE, Yurika MIYOSHI, Ryohei YAMAMOTO, Keiko YASUDA, Masashi MITA, Hiromi RAKUGI, Terumasa HAYASHI, Yoshitaka ISAKA, Chiral amino acid metabolomics for novel biomarker screening in the prognosis of chronic kidney disease,
Scientific Reports
, 6,26137 (2016), DOI:10.1038/srep26137


 
Minoru TANIGAWA, Chihiro SUZUKI, Kimio NIWANO, Rensuke KANEKATSU, Hiroyuki TANAKA, Kihachiro HORIIKE, Kenji HAMASE, Yoko NAGATA, Participation of D-serine in the development and reproduction of the silkworm Bombyx mori,
Journal of Insect Physiology
, 87, 20-29 (2016). DOI: 10.1016/j.jinsphys.2016.01.006


Reiko KOGA, Yurika MIYOSHI, Yu SATO, Masashi MITA, Ryuichi KONNO, Wolfgang LINDNER, Kenji HAMASE, Enantioselective determination of phenylalanine, tyrosine and 3,4-dihydroxyphenylalanine in the urine of D-amino acid oxidase deficient mice using two-dimensional high-performance liquid chromatography,
Chromatography
, 37, 1, 15-22 (2016) , DOI:10.15583/jpchrom.2015.040
 

  2015

Shu-Ling LIU, Tsubasa OYAMA, Yurika MIYOSHI, Shiow-Yunn SHEU, Masashi MITA, Tomomi IDE, Wolfgang LINDNER, Kenji HAMASE, Jen-Ai LEE, Establishment of a two-dimensional chiral HPLC system for the simultaneous detection of lactate and 3-hydroxybutyrate enantiomers in human clinical samples,
Journal of Pharmaceutical and Biomedical Analysis, 116, 80-85 (2015). DOI:10.1016/j.jpba.2015.05.036

 

Tsubasa OYAMA, Eiichi NEGISHI, Hirohisa ONIGAHARA, Nao KUSANO, Yurika MIYOSHI, Masashi MITA, Manabu NAKAZONO, Sumio OHTSUKI, Akio OJIDA, Wolfgang LINDNER, Kenji HAMASE, Design and synthesis of a novel pre-column derivatization reagent with a 6-methoxy-4-quinolone moiety for fluorescence and tandem mass spectrometric detection and its application to chiral amino acid analysis,
Journal of Pharmaceutical and Biomedical Analysis,116,71-79(2015)
. DOI:10.1016/j.jpba.2015.05.039

Hai HAN, Yurika MIYOSHI, Reiko KOGA, Masashi MITA, Ryuichi KONNO, Kenji HAMASE, Changes in D-aspartic acid and D-glutamic acid levels in the tissues and physiological fluids of mice with various D-aspartate oxidase activities,
Journal of Pharmaceutical and Biomedical Analysis, 116, 47-52 (2015). DOI:10.1016/j.jpba.2015.05.013


Tsubasa OYAMA, Rie NAGAI, Mayumi FUJIMOTO, Ryoko KONISHI, Masashi MITA, Keiko UEZONO, Kiyoshi ZAITSU, Kenji HAMASE, Development of a fully-automated on-line oxidation column-switching HPLC system for the determination of endogenous melatonin in human clinical samples,
Analytical Sciences
, 31(11),1129-1135(2015).
 DOI10.2116/analsci.31.1129

Sachise KARAKAWA, Kazutaka SHIMBO, Naoyuki YAMADA, Toshimi MIZUKOSHI, Hiroshi MIYANO, Masashi MITA, Wolfgang LINDNER, Kenji HAMASE, Simultaneous analysis of D-alanine, D-aspartic acid, and D-serine using chiral high-performance liquid chromatography-tandem mass spectrometry and its application to the rat plasma and tissues,
Journal of Pharmaceutical and Biomedical Analysis, 115,123-129,(2015).
DOI:10.1016/j.jpba.2015.05.024
 

Shoto ISHIGO, Eiichi NEGISHI, Yurika MIYOSHI, Hirohisa ONIGAHARA, Masashi MITA, Tetsuya MIYAMOTO, Haruhiko MASAKI, Hiroshi HOMMA, Tadashi UEDA, Kenji HAMASE, Establishment of a two-dimensional HPLC-MS/MS method combined with DC1/D2O hydrolysis for the determination of trace amounts of D-amino acid residues in proteins,
Chromatography, 36, 45-50 (2015). DOI:10.15583/jpchrom.2015.017


Masataka SUZUKI, Jumpei SASABE, Yurika MIYOSHI, Kenji HAMASE, Masaaki MATSUOKA, Nobuaki IMANISHI, Sadakazu AISO, Glycolytic flux controls D-serine synthesis through glyceraldehyde-3-phosphate dehydrogenase in astrocytes,
Proceedings of the National Academy of Sciences of the United States of America
, 112, E2217-2224 (2015). DOI: 10.1073/pnas.1416117112
 
Printip WONGTHAI, Kohei HAGIWARA, Yurika MIYOSHI, Pattama WIRIYASERMKUL, Ling WEI, Ryuichi OHGAKI, Itsuro KATO, Kenji HAMASE, Shushi NAGAMORI, Yoshikatsu KANAI, Boronophenylalanine, a boron delivery agent for boron neutron capture therapy, is transported by ATB0, +, LAT1 and LAT2,
Cancer Science
,
106, 279-286 (2015). DOI: 10.1111/cas.12602

Hiroshi HAMAMOTO, Makoto URAI, Kenichi ISHII, Jyunichiro YASUKAWA, Atmika PAUDEL, Motoki MURAI, Takuya KAJI, Takefumi KURANAGA, Kenji HAMASE, Takashi KATSU, Jie SU, Tatsuo ADACHI, Ryuji UCHIDA, Hiroshi TOMODA, Maki YAMADA, Manabu SOUMA, Hiroki KURIHARA, Masayuki INOUE, Kazuhisa SEKIMIZU, Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane,
Nature Chemical Biology, 11, 127-133 (2015). DOI:10.1038/nchembio.1710
 

Takato ABE, Masataka SUZUKI, Jumpei SASABE, Shinichi TAKAHASHI, Miyuki UNEKAWA, Kyoko MASHIMA, Takuya IIZUMI, Kenji HAMASE, Ryuichi KONNO, Sadakazu AISO, Norihiro SUZUKI, Cellular origin and regulation of D- and L-serine in in vitro and in vivo models of cerebral ischemia,
Journal of Cerebral Blood Flow and Metabolism
,
 34, 1928-1935 (2014). DOI: 10.1038/jcbfm.2014.164

 International Conference  
  2017

Chin-Ling HSIEH, Aogu FURUSHO, Masashi MITA, Tomomi IDE, Jen-Ai LEE, Kenji HAMASE, Enantioselective and simultaneous determination of lactate and 3-hydroxybutyrate in human clinical samples using a narrowbore two-dimensional HPLC system,
The 3rd International Conference of
D-Amino Acid Research, (Varese, Italy, 2017 July 10), P63.

 

Kenji HAMASE, Reiko KOGA, Yurika MIYOSHI, Masashi MITA, Jen-Ai LEE, Wolfgang LINDNER, Multi-dimensional HPLC analysis of D-amino acids and related compounds in complicated biological matrices and its clinical applications,
The 3rd International Conference of
D-Amino Acid Research, (Varese, Italy, 2017 July 11), P14.

 
Reiko KOGA, Yu SATO, Masashi MITA, Hiroshi NARAOKA, Kenji HAMASE, Multi-dimensional HPLC analysis of extraterrestrial amino acid enantiomers in various cosmic samples,
The 3rd International Conference of
D-Amino Acid Research, (Varese, Italy, 2017 July 10), P6.

Kenji UEKI, Takeyuki AKITA, Yasuhiko KADOTA, Yasuhiro NISHIO, Yurika MIYOSHI, Masashi MITA, Akio OJIDA, Kenji HAMASE, Development of high resolusion Pirkle-type chiral stationary phases and application to D-amino acid analysis in biological matrices,
45th International Symposium on High Performance Liquid Phase Separations and Related Techniques (Prague, Czech Republic, 2017 June 19), P122.

 

Chiharu ISHII, Tetsuya MIYAMOTO, Shoto ISHIGO, Masashi MITA, Hiroshi HOMMA, Tadashi UEDA, Kenji HAMASE, Accumulation of D-amino acid residues in various proteins during storage,
45
th International Symposium on High Performance Liquid Phase Separations and Related Techniques (Prague, Czech Republic, 2017 June 19), P122.

 
Kenji HAMASE, Reiko KOGA, Yurika MIYOSHI, Masashi MITA, Wolfgang LINDNER, Three-demensional HPLC analysis of amino acid enantiomers in complicated real world samples,
45
th International Symposium on High Performance Liquid Phase Separations and Related Techniques (Prague, Czech Republic, 2017 June 20), P55. 

Kenji HAMASE, Multi-dimensional HPLC analysis of chiral amino acids for drug discovery and diagnosis,
The JSPS-NRCT Follow-Up Seminar 2017 and 33rd International Annual Meeting in Pharmaceutical Sciences, (Bangkok, Thailand, 2017 March 2) P61.

 

  2016
 

Yu SATO, Reiko KOGA, Masashi MITA, Hiroshi NARAOKA, Kenji HAMASE, Enantioselective two-dimensional HPLC determination of α-amino acids in extraterrestrial samples,
XVII International Symposium on Luminescence Spectrometry, (Taipei, Taiwan, 2016 November 23), P133.

 

Reiko KOGA, Yu SATO, Kenji UEKI, Yasuhiko KADOTA, Yasuhiro NISHIO, Masashi MITA, Tomomi IDE, Kenji HAMASE, Design and development of an enansioselective three-dimensional HPLC system for the highly selective fluorescence determination of chiral amino acids,
XVII International Symposium on Luminescence Spectrometry, (Taipei, Taiwan, 2016 November 23), P133.

 
Kentaro KOBAYASHI, Yumi IWASHITA, Reiko KOGA, Yurika MIYOSHI, Muneki ISOKAWA, Masashi MITA, Makoto TSUNODA, Tadashi UEDA, Kenji HAMASE, Simultaneous determination of sulfur-containing amino acid stereoisomers using a 2D-HPLC system in the urine of homocystinuria model with cystathionine β-synthase deficiency, XVII International Symposium on Luminescence Spectrometry, (Taipei, Taiwan, 2016 November 23), P133. 

Kenji UEKI, Takeyuki AKITA, Yu SATO, Reiko KOGA, Yasuhiko KADOTA, Yasuhiro NISHIO, Yurika MIYOSHI, Masashi MITA, Akio OJIDA, Kenji HAMASE, Design of a novel high resolution Pirkle-type chiral stationary phase and separation of NBD-amino acid enantiomers,
XVII International Symposium on Luminescence Spectrometry, (Taipei, Taiwan, 2016 November 23), P133.

 

Yuki MAEDA, Yu,SATO, Reiko KOGA, Yurika MIYOSHI, Yasuhiko KADOTA, Yasuhiro NISHIO, Masashi MITA, Kenji HAMASE, Development of a highly sensitive micro-2D-HPLC system for chiral amino acid metabolomics,
XVII International Symposium on Luminescence Spectrometry, (Taipei, Taiwan, 2016 November 23), P133.

 

Kenji HAMASE, Reiko KOGA, Takeyuki AKITA, Yurika MIYOSHI, Masashi MITA, Hiroshi NARAOKA, Wolfgang LINDNER, Chiral amino acid metabolomics using multi-dimensional HPLC,
XVII International Symposium on Luminescence Spectrometry, (Taipei, Taiwan, 2016 November 24), P62.

 

Yurika MIYOSHI, Maiko NAKANE, Yoshikazu SUGITO, Yosuke TOJO, Reiko KOGA, Masanobu NAGANO, Masashi MITA, Kenji HAMASE, Two-demensional HPLC-FL determination of chiral amino acids in foodstuffs,
XVII International Symposium on Luminescence Spectrometry, (Taipei, Taiwan, 2016 November 23), P35.

 

Chiharu ISHII, Shoto ISHIGO, Tetsuya MIYAMOTO, Yurika MIYOSHI, Masashi MITA, Hiroshi HOMMA, Tadashi UEDA, Kenji HAMASE, Determination of D-amino acid residues in proteins stored under various pH conditions,
27th International Symposium on Pharmaceutical and Biomedical Analysis, (Guangzhou, China, 2016 November 14), P.364.

 

Kenji HAMASE, Reiko KOGA, Yurika MIYOSHI, Masashi MITA, Wolfgang LINDNER, Chiral amino acid analysis: New frontier of drug discovery and diagnosis,
27th International Symposium on Pharmaceutical and Biomedical Analysis, (Guangzhou, China, 2016 November 14), P50.

 

Yuko SAITSU, Yurika MIYOSHI, Yu SATO, Eiichi NEGISHI, Takafumi SUMIYAMA, Masanobu NAGANO, Masashi MITA, Kenji HAMASE, Development of a 2D-HPLC system for NBD-amino acids using a blue LED fluorescence detector and determination of amino acid enantiomers in fermented products,
44th International Symposium on High-Performance Liquid Phase Separations and Related Techniques (San Francisco, CA, USA, 2016 June 23), P229.

 
Reiko KOGA, Yurika MIYOSHI, Yu SATO, Masashi MITA, Ryuichi KONNO, Wolfgang LINDNER, Kenji HAMASE, Enantioselective 2D-HPLC determination of citrulline and ornithine in the urine of D-amino acid oxidase deficient mice,
44th International Symposium on High-Performance Liquid Phase Separations and Related Techniques (San Francisco, CA, USA, 2016 June 21), P105.

Kenji HAMASE, Yurika MIYOSHI, Masashi MITA, Wolfgang LINDNER, Chiral amino acid targeted metabolomics as a new strategy for biomarker screening and designing functional foods/beverages,
44th International Symposium on High-Performance Liquid Phase Separations and Related Techniques (San Francisco, CA, USA, 2016 June 23), P55-56.

 
  2015
Yurika MIYOSHI, Jumpei SASABE, Masataka SUZUKI, Yayoi YONENAGA, Yu SATO, Maiko NAKANE, Masashi MITA, Sadakazu AISO, Kenji HAMASE, Two-dimensional HPLC-FL/MS/MS determination of chiral amino acids in physiological fluids of model mice of ischemic acute kidney injury,
26th International Symposium on Pharmaceutical and Biomedical Analysis, (Tbilisi, Georgia, 2015 July), P166.
 

Kenji HAMASE, Yurika MIYOSHI, Masashi MITA, Wolfgang LINDNER, Chiral amino acid metabolomics for drug discovery, clinical diagnosis and designing functional foods/ beverages,
26th International Symposium on Pharmaceutical and Biomedical Analysis, (Tbilisi, Georgia, 2015 July), P25.

 

Reiko KOGA, Yurika MIYOSHI, Hirohisa ONIGAHARA, Masashi MITA, Ryuichi KONNO, Wolfgang LINDNER, Kenji HAMASE, Enantioselective determination of phenylalanine, tyrosine and 3,4-dihydroxyphenylalanine in the model mice with metabolic disorders,
42nd
International Symposium on High Performance Liquid Phase Separations and Related Techniques, (Geneva, Switzerland, 2015 June), P314.

 
Shoto ISHIGO, Eiichi NEGISHI, Yurika MIYOSHI, Hirohisa ONIGAHARA, Masashi MITA, Tadashi UEDA, Kenji HAMASE, Determination of trace levels of D-Asp and D-Glu residues in proteins using a two-dimensional HPLC-MS/MS system,
42nd
International Symposium on High Performance Liquid Phase Separations and Related Techniques, (Geneva, Switzerland, 2015 June), P313.
 

Kenji HAMASE, Yurika MIYOSHI, Yayoi YONENAGA, Hirohisa ONIGAHARA, Yusuke ITO, Masashi MITA, Jumpei SASABE, Sadakazu AISO, Wolfgang LINDNER, Chiral amino acid targeted metabolomics for clinical diagnosis using enantioselective two-dimensional HPLC tandem-mass spectrometry,
42nd International Symposium on High Performance Liquid Phase Separations and Related Techniques, (Geneva, Switzerland, 2015 June), P42.

 
Ryosuke MATSUKANE, Tsukasa SHIMAUCHI, Akiyuki NISHIMURA, Takuro TOMITA, Motohiro NISHIDA, Improvement of peripheral arterial disease by a novel TRPC3/6-selective inhibitor,
TRPs and SOCs ~Unconventional Ca2+ Physioligy~ (Okazaki,2015 June), P12.