Graduate School of Pharmaceutical Sciences, Kyushu University
Drug Discovery and Evolution
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2013-2015
 Research Paper in English
  2018

Masumi KATANE, Makoto ARIYOSHI, Shuhei TATEISHI, Sachi KOIWAI, Kaoruko TAKAKU, Kenichiro NAGAI, Kazuki NAKAYAMA, Yasuaki SAITOH, Tetsuya MIYAMOTO, Masae SEKINE, Masashi MITA, Kenji HAMASE, Satoaki MATOBA, Hiroshi HOMMA, Structural and enzymatic properties of mammalian D-glutamate cyclase, Archives of Biochemistry and Biophysics, in press,

 

Yusuke NAKADE, Yasunori IWATA, Kengo FURUICHI, Masashi MITA, Kenji HAMASE, Ryuichi KONNO, Taito MIYAKE, Norihiko SAKAI, Shinji KITAJIMA, Tadashi TOYAMA, Yasuyuki SHINOZAKI, Akihiro SAGARA, Taro MIYAGAWA, Akinori HARA, Miho SHIMIZU, Yasutaka KAMIKAWA, Kouichi SATO, Megumi OSHIMA, Shiori YONEDA-NAKAGAWA, Yuta Yamamura, Shuichi KANEKO, Tetsuya MIYAMOTO, Masumi KATANE, Hiroshi HOMMA, Hidetoshi MORITA, Wataru SUDA, Masahira HATTORI, Takashi WADA, Gut microbiota-derived D-serine protects from acute kidney injury,
JCI Insight
, in press,

 

Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Kenji HAMASE, Development of an online two-dimensional high-performance liquid chromatographic system in combination with tandem mass spectrometric detection for enantiomeric analysis of free amino acids in human physiological fluid,
Journal of Chromatography A
, 1570, 91-98 (2018), DOI:10.1016/j.chroma.2018.07.076

 

Aogu FURUSHO, Reiko KOGA, Takeyuki AKITA, Yurika MIYOSHI, Masashi MITA, Kenji HAMASE, Development of a highly-sensitive two-dimensional HPLC system with narrowbore reversed-phase and microbore enantioselective columns and application to the chiral amino acid analysis of the mammalian brain,
Chromatography
,39, 83-90 (2018) , DOI:10.15583/jpchrom.2018.007

 

Nutchaya SEREEKITTIKUL, Reiko KOGA, Takeyuki AKITA, Aogu FURUSHO, Roland REISCHL, Masashi MITA, Akira FUJII, Kazunori HASHIGUCHI, Masanobu NAGANO, Wolfgang LINDNER, Kenji HAMASE, Multi-dimensional HPLC analysis of serine containing chiral dipeptides in Japanese traditional amber rice vinegar,
Chromatography, 39, 59-66 (2018), DOI:10.15583/jpchrom.2018.002

 
Chin-Ling HSIEH, Reiko KOGA, Aogu FURUSHO, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Jen-Ai LEE, Kenji HAMASE, Enantioselective and simultaneous determination of lactate and 3-hydroxybutyrate in human plasma and urine using a narrowbore online two-dimensional HPLC system,
Journal of Separation Science, 41, 1298-1306 (2018) , DOI:10.1002/jssc.201701283


  2017

Chiharu ISHII, Tetsuya MIYAMOTO, Shoto ISHIGO, Yurika MIYOSHI, Masashi MITA, Hiroshi HOMMA, Tadashi UEDA, Kenji HAMASE, Two-dimensional HPLC-MS/MS determination of multiple D-amino acid residues in the proteins stored under various pH conditions,
Chromatography
, 38, 65-72 (2017), DOI:10.15583/jpchrom.2017.009

 

Akiko MORIKAWA, Hideoki FUKUOKA, Keiko UEZONO, Masashi MITA, Satoru KOYANAGI, Shigehiro OHDO, Kiyoshi ZAITSU, Kenji HAMASE, Sleep-awake profile related circadian D-alanine rhythm in human serum and urine, Chromatography, 38,53-58(2017), DOI:10.15583/jpchrom.2017.003

 

Makoto ARIYOSHI, Masumi KATANE, Kenji HAMASE, Yurika MIYOSHI, Maiko NAKANE, Atsushi HOSHINO, Yoshifumi OKAWA, Yuichiro MITA, Satoshi KAIMOTO, Motoki UCHIHASHI, Kuniyoshi FUKAI, Kazunori ONO, Syuhei TATEISHI, Daichi HATO, Ryoetsu YAMANAKA, Sakiko HONDA, Yohei FUSHIMURA, Eri IWAI-KANAI, Naotada ISHIHARA, Masashi MITA, Hiroshi HOMMA, Satoaki MATOBA, D-Glutamate is metabolized in the heart mitochondria,
Scientific Reports,7, 43911 (2017), DOI:10.1038/srep43911

 
  2016

Muneki ISOKAWA, Kentaro KOBAYASHI, Yurika MIYOSHI, Masashi MITA, Takashi FUNATSU, Kenji HAMASE, Makoto TSUNODA, Quantification of biological thiols in the plasma of a homocystinuria model with cystathionine β-synthase deficiency utilizing hydrophilic interaction liquid chromatography and fluorescence detection,
Chromatography, 37, 147-151 (2016), DOI:10.15583/jpchrom.2016.015


Reiko KOGA, Yurika MIYOSHI, Yu SATO, Masashi MITA, Ryuichi KONNO, Wolfgang LINDNER, Kenji HAMASE, Enantioselective determination of citrulline and ornithine in the urine of D-amino acid oxidase deficient mice using a two-dimensional high-performance liquid chromatographic system,
Journal of Chromatography A
, 1467, 312-317 (2016), DOI:10.1016/j.chroma.2016.07.053

 

Jumpei SASABE, Yurika MIYOSHI, Seth Rakoff-NAHOUM, Ting ZHANG, Masashi MITA, Brigid M. DAVIS, Kenji HAMASE, Matthew K. WALDOR, Interplay between microbial D-amino acids and host D-amino acid oxidase modifies murine mucosal defence and gut microbiota,
Nature Microbiology, 1, 16125, (2016), DOI:10.1038/nmicrobiol.2016.125


Tomonori KIMURA, Kenji HAMASE, Yurika MIYOSHI, Ryohei YAMAMOTO, Keiko YASUDA, Masashi MITA, Hiromi RAKUGI, Terumasa HAYASHI, Yoshitaka ISAKA, Chiral amino acid metabolomics for novel biomarker screening in the prognosis of chronic kidney disease,
Scientific Reports
, 6,26137 (2016), DOI:10.1038/srep26137


 
Minoru TANIGAWA, Chihiro SUZUKI, Kimio NIWANO, Rensuke KANEKATSU, Hiroyuki TANAKA, Kihachiro HORIIKE, Kenji HAMASE, Yoko NAGATA, Participation of D-serine in the development and reproduction of the silkworm Bombyx mori,
Journal of Insect Physiology
, 87, 20-29 (2016). DOI: 10.1016/j.jinsphys.2016.01.006


Reiko KOGA, Yurika MIYOSHI, Yu SATO, Masashi MITA, Ryuichi KONNO, Wolfgang LINDNER, Kenji HAMASE, Enantioselective determination of phenylalanine, tyrosine and 3,4-dihydroxyphenylalanine in the urine of D-amino acid oxidase deficient mice using two-dimensional high-performance liquid chromatography,
Chromatography
, 37, 1, 15-22 (2016) , DOI:10.15583/jpchrom.2015.040
 


 International Conference  
  2018

Takeyuki AKITA, Asumi YOSHIDA, Masashi MITA, Akio OJIDA, Kenji HAMASE, A novel fluorescence derivatizing reagent for chiral amino acid metabolome analysis including tryptophan with high emission intensity,
15th Conference of the International Society of Tryptophan Research (Hikone, 2018 September 20), P98.

 

Kenji HAMASE, Chiral amino acid analysis using multi-dimensional HPLC: A new frontier of the amino acid and protein research,
15th Conference of the International Society of Tryptophan Research (Hikone, 2018 September 20), P67.

 
Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Kenji HAMASE, Development and validation of an on-line two-dimensional HPLC-MS/MS system for the determination of intrinsic chiral amino acids in human physiological fluids,
The 11th International Symposium on Drug Analysis & The 29th International Symposium on Pharmaceutical and Biomedical Analysis (Leuven, Belgium, 2018 September 9-12)


Kenji HAMASE, Chiharu ISHII, Aogu FURUSHO, Reiko KOGA, Takeyuki AKITA, Masashi MITA, Masanobu NAGANO, Tomomi IDE, Tomonori KIMURA, Wolfgang LINDNER, Chiral amino acid metabolomics studies using two/three-dimensional HPLC for the screening of new biomarkers and designing functional foods/beverages,
The 11th International Symposium on Drug Analysis & The 29th International Symposium on Pharmaceutical and Biomedical Analysis (Leuven, Belgium, 2018 September 10)

 

Takeyuki AKITA, Kenji UEKI, Masashi MITA, Kenji HAMASE, Design and development of multi-mode HPLC stationary phases for chiral separation of amino acids and related compounds,
25th International Symposium on Electro-and Liquid Phase-Separation Techniques (Kyoto, 2018 August 31), IN-1.


Kenji HAMASE, Reiko KOGA, Aogu FURUSHO, Chin-Ling HSIEH, Nutchaya SEREEKITTIKUL, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Jen-Ai LEE, Wolfgang LINDNER, Three-dimensional chiral HPLC analysis of amino acids and related compounds in complex biological matrices including human clinical samples,
47
th International Symposium on High Performance Liquid Phase Separations and Related Techniques (Washington, DC, USA, 2018 August 2), P71.


Reiko KOGA, Ena YANO, Tomoko SHINOJIMA, Masashi MITA, Tomomi IDE, Hideyuki YOSHIDA, Hitoshi NOHTA, Kenji HAMASE, Enantioselective and simultaneous 2D-HPLC determination of citrulline and homocitrulline in human clinical samples,
47th International Symposium on High Performance Liquid Phase Separations and Related Techniques (Washington, DC, USA, 2018 July 31), P191.

Aogu FURUSHO, Reiko KOGA, Takeyuki AKITA, Masashi MITA, Tomonori KIMURA, Kenji HAMASE, Three-dimensional HPLC analysis of chiral amino acids in the plasma of patients with chronic kidney disease,
47
th International Symposium on High Performance Liquid Phase Separations and Related Techniques (Washington, DC, USA, 2018 July 31), P149.

 

Aogu FURUSHO, Reiko KOGA, Takeyuki AKITA, Masashi MITA, Tomonori KIMURA, Kenji HAMASE, Development of a three-dimensional HPLC system and application to the chiral amino acid analysis in the plasma of patients with kidney disfunction,
2018 Sino-Japanese Joint Symposium on Separation Sciences (Dalian, China, July 11-12), P87

 

 
Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Kenji HAMASE, Selective screening of free D-amino acids in the physiological fluids and D-form residues in the proteins using an automated two-dimensional HPLC-MS/MS system,
2018 Sino-Japanese Joint Symposium on Separation Sciences (Dalian, China, July 11-12), P86.

Kenji HAMASE, Multi-dimensional chiral HPLC: A promising approach to expand the frontier of amino acid, peptide and protein research,
2018 Sino-Japanese Joint Symposium on Separation Sciences (Dalian, China, July 12), P53.

 

Pitchapa PUTRAKUL, Nutchaya SEREEKITTIKUL, Chiharu ISHII, Panitch BOONSNONGCHEEP, Kenji HAMASE, Benyakan PONGKITWITOON, Development of a microbore reverse-phase HPLC for determination of capsaicinoids in Capsicum extracts,
The 5th International Conference on Current Drug Development 2018 (CDD 2018) and The 3rd International Conference on Herbal and Traditional Medicine 2018 (HTM 2018) (Songkhla, Thailand, 2018 May 23-25), P123.

 

 

Chin-Ling HSIEH, Masashi MITA, Tomomi IDE, Jen-Ai LEE, Kenji HAMASE, Development of a three-dimensional HPLC system with fluorescence detection for the simultaneous determination of lactate and 3-hydroxybutyrate enantiomers in human clinical samples,
XVIII International Symposium on Luminescence Spectrometry (Brest, France, 2018 June 19-22), P31.

 

Kenji HAMASE, Multi-dimensional HPLC with fluorescence detection as a promising method for trace analysis of chiral amino acids and hydroxy acids in clinical, food and extraterrestrial samples,
XVIII International Symposium on Luminescence Spectrometry (Brest, France, 2018 June 20), P14.

 

 
Siralak LAORATANAPONG, Nutchaya SEREEKITTIKUL, Kenji UEKI, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Boonchoo SRITULARAK, Kenji HAMASE, Two-dimensional HPLC analysis of Asp-Gly and Gly-Asp enantiomers in human samples and fermented products,
34th International Annual Meeting In Pharmaceutical Sciences & 2nd CU FPHS-RIKEN CDB Symposium,
(Bangkok, Thailand, 2018 March 8-9), P74.

Best Poster Award

Chiharu ISHII, Masashi MITA, Takeyuki AKITA, Tomomi IDE, Kenji HAMASE, Development of a fully automated two-dimensional HPLC-MS/MS system for the determination of amino acid enantiomers in human physiological fluids and fermented beverages,
34th International Annual Meeting In Pharmaceutical Sciences & 2nd CU FPHS-RIKEN CDB Symposium,
(Bangkok, Thailand, 2018 March 8-9), P61.

  2017
Kenji HAMASE, Takeyuki AKITA, Masashi MITA, Hiroshi NARAOKA, Wolfgang LINDNER, Multi-dimensional chiral HPLC analysis of amino acids in clinical samples and extraterrestrial materials,
The 46
th International Symposium on High Performance Liquid Phase Separations and Related Techniques (Jeju, Korea, 2017 November 9), K39. 

Nutchaya SEREEKITTIKUL, Reiko KOGA, Aogu FURUSHO, Roland REISCHL, Masashi MITA, Masanobu NAGANO, Tomomi IDE, Wolfgang LINDNER, Kenji HAMASE, Multi-dimensional HPLC analysis of serine containing chiral depeptides in human physiological fluids and fermented products,
The 46
th International Symposium on High Performance Liquid Phase Separations and Related Techniques (Jeju, Korea, 2017 November 7), PT019.

Kenta SAKAI, Kenji UEKI, Reiko KOGA, Yurika MIYOSHI, Takeyuki AKITA, Masashi MITA, Ryuichi KONNO, Tomomi IDE, Kenji HAMASE, Development of a two-dimensional chiral HPLC system for leucine structural isomers and determination of their urinary levels,
The 46
th International Symposium on High Performance Liquid Phase Separations and Related Techniques (Jeju, Korea, 2017 November 7), PT017.

Best Poster Award

 
Aogu FURUSHO, Reiko KOGA, Yurika MIYOSHI, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Kenji HAMASE, Design and development of a three-dimensional HPLC system for chiral amino acid analysis in human clinical samples,
The 46th International Symposium on High Performance Liquid Phase Separations and Related Techniques (Jeju, Korea, 2017 November 6), PM022.

 

Chin-Ling HSIEH, Aogu FURUSHO, Masashi MITA, Tomomi IDE, Jen-Ai LEE, Kenji HAMASE, Enantioselective and simultaneous determination of lactate and 3-hydroxybutyrate in human clinical samples using a narrowbore two-dimensional HPLC system,
The 3rd International Conference of
D-Amino Acid Research, (Varese, Italy, 2017 July 10), P63.

 

Kenji HAMASE, Reiko KOGA, Yurika MIYOSHI, Masashi MITA, Jen-Ai LEE, Wolfgang LINDNER, Multi-dimensional HPLC analysis of D-amino acids and related compounds in complicated biological matrices and its clinical applications,
The 3rd International Conference of
D-Amino Acid Research, (Varese, Italy, 2017 July 11), P14.

 
Reiko KOGA, Yu SATO, Masashi MITA, Hiroshi NARAOKA, Kenji HAMASE, Multi-dimensional HPLC analysis of extraterrestrial amino acid enantiomers in various cosmic samples,
The 3rd International Conference of
D-Amino Acid Research, (Varese, Italy, 2017 July 10), P6.

Kenji UEKI, Takeyuki AKITA, Yasuhiko KADOTA, Yasuhiro NISHIO, Yurika MIYOSHI, Masashi MITA, Akio OJIDA, Kenji HAMASE, Development of high resolusion Pirkle-type chiral stationary phases and application to D-amino acid analysis in biological matrices,
45th International Symposium on High Performance Liquid Phase Separations and Related Techniques (Prague, Czech Republic, 2017 June 19), P122.

 

Chiharu ISHII, Tetsuya MIYAMOTO, Shoto ISHIGO, Masashi MITA, Hiroshi HOMMA, Tadashi UEDA, Kenji HAMASE, Accumulation of D-amino acid residues in various proteins during storage,
45
th International Symposium on High Performance Liquid Phase Separations and Related Techniques (Prague, Czech Republic, 2017 June 19), P122.

 
Kenji HAMASE, Reiko KOGA, Yurika MIYOSHI, Masashi MITA, Wolfgang LINDNER, Three-demensional HPLC analysis of amino acid enantiomers in complicated real world samples,
45
th International Symposium on High Performance Liquid Phase Separations and Related Techniques (Prague, Czech Republic, 2017 June 20), P55. 

Kenji HAMASE, Multi-dimensional HPLC analysis of chiral amino acids for drug discovery and diagnosis,
The JSPS-NRCT Follow-Up Seminar 2017 and 33rd International Annual Meeting in Pharmaceutical Sciences, (Bangkok, Thailand, 2017 March 2) P61.

 

  2016
 

Yu SATO, Reiko KOGA, Masashi MITA, Hiroshi NARAOKA, Kenji HAMASE, Enantioselective two-dimensional HPLC determination of α-amino acids in extraterrestrial samples,
XVII International Symposium on Luminescence Spectrometry, (Taipei, Taiwan, 2016 November 23), P133.

 

Reiko KOGA, Yu SATO, Kenji UEKI, Yasuhiko KADOTA, Yasuhiro NISHIO, Masashi MITA, Tomomi IDE, Kenji HAMASE, Design and development of an enansioselective three-dimensional HPLC system for the highly selective fluorescence determination of chiral amino acids,
XVII International Symposium on Luminescence Spectrometry, (Taipei, Taiwan, 2016 November 23), P133.

 
Kentaro KOBAYASHI, Yumi IWASHITA, Reiko KOGA, Yurika MIYOSHI, Muneki ISOKAWA, Masashi MITA, Makoto TSUNODA, Tadashi UEDA, Kenji HAMASE, Simultaneous determination of sulfur-containing amino acid stereoisomers using a 2D-HPLC system in the urine of homocystinuria model with cystathionine β-synthase deficiency, XVII International Symposium on Luminescence Spectrometry, (Taipei, Taiwan, 2016 November 23), P133. 

Kenji UEKI, Takeyuki AKITA, Yu SATO, Reiko KOGA, Yasuhiko KADOTA, Yasuhiro NISHIO, Yurika MIYOSHI, Masashi MITA, Akio OJIDA, Kenji HAMASE, Design of a novel high resolution Pirkle-type chiral stationary phase and separation of NBD-amino acid enantiomers,
XVII International Symposium on Luminescence Spectrometry, (Taipei, Taiwan, 2016 November 23), P133.

 

Yuki MAEDA, Yu,SATO, Reiko KOGA, Yurika MIYOSHI, Yasuhiko KADOTA, Yasuhiro NISHIO, Masashi MITA, Kenji HAMASE, Development of a highly sensitive micro-2D-HPLC system for chiral amino acid metabolomics,
XVII International Symposium on Luminescence Spectrometry, (Taipei, Taiwan, 2016 November 23), P133.

 

Kenji HAMASE, Reiko KOGA, Takeyuki AKITA, Yurika MIYOSHI, Masashi MITA, Hiroshi NARAOKA, Wolfgang LINDNER, Chiral amino acid metabolomics using multi-dimensional HPLC,
XVII International Symposium on Luminescence Spectrometry, (Taipei, Taiwan, 2016 November 24), P62.

 

Yurika MIYOSHI, Maiko NAKANE, Yoshikazu SUGITO, Yosuke TOJO, Reiko KOGA, Masanobu NAGANO, Masashi MITA, Kenji HAMASE, Two-demensional HPLC-FL determination of chiral amino acids in foodstuffs,
XVII International Symposium on Luminescence Spectrometry, (Taipei, Taiwan, 2016 November 23), P35.

 

Chiharu ISHII, Shoto ISHIGO, Tetsuya MIYAMOTO, Yurika MIYOSHI, Masashi MITA, Hiroshi HOMMA, Tadashi UEDA, Kenji HAMASE, Determination of D-amino acid residues in proteins stored under various pH conditions,
27th International Symposium on Pharmaceutical and Biomedical Analysis, (Guangzhou, China, 2016 November 14), P.364.

 

Kenji HAMASE, Reiko KOGA, Yurika MIYOSHI, Masashi MITA, Wolfgang LINDNER, Chiral amino acid analysis: New frontier of drug discovery and diagnosis,
27th International Symposium on Pharmaceutical and Biomedical Analysis, (Guangzhou, China, 2016 November 14), P50.

 

Yuko SAITSU, Yurika MIYOSHI, Yu SATO, Eiichi NEGISHI, Takafumi SUMIYAMA, Masanobu NAGANO, Masashi MITA, Kenji HAMASE, Development of a 2D-HPLC system for NBD-amino acids using a blue LED fluorescence detector and determination of amino acid enantiomers in fermented products,
44th International Symposium on High-Performance Liquid Phase Separations and Related Techniques (San Francisco, CA, USA, 2016 June 23), P229.

 
Reiko KOGA, Yurika MIYOSHI, Yu SATO, Masashi MITA, Ryuichi KONNO, Wolfgang LINDNER, Kenji HAMASE, Enantioselective 2D-HPLC determination of citrulline and ornithine in the urine of D-amino acid oxidase deficient mice,
44th International Symposium on High-Performance Liquid Phase Separations and Related Techniques (San Francisco, CA, USA, 2016 June 21), P105.

Kenji HAMASE, Yurika MIYOSHI, Masashi MITA, Wolfgang LINDNER, Chiral amino acid targeted metabolomics as a new strategy for biomarker screening and designing functional foods/beverages,
44th International Symposium on High-Performance Liquid Phase Separations and Related Techniques (San Francisco, CA, USA, 2016 June 23), P55-56.